ersentilide

has class II & III activities; RN given refers to (+-)-isomer; structure given in first source; CK-4000 (S- isomer); CK-4001 (R- isomer)

Also Known As:

4-HIPPM; CK 3579; CK 4000; CK 4001; CK-3579; CK-4000; CK-4001; HE 93; HE-93; HE93; N-(4-(2-hydroxy-3-((2-(4-(1H-imidazol-1-yl)phenoxy)ethyl)amino)propoxy)phenyl)methanesulfonamide; ersentilide hydrochloride, (+-)-isomer; ersentilide hydrochloride, (R)-isomer; ersentilide hydrochloride, (S)-isomer; ersentilide, (R)-isomer; ersentilide, (S)-isomer; ersentilide, malate salt, (S)-isomer

Networked: 4 relevant articles (2 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Bernal, William: 1 article (09/2010)
2.	McPhail, Mark J W: 1 article (09/2010)
3.	Wendon, Julia A: 1 article (09/2010)

Related Diseases

1.	Myocardial Infarction 10/01/1998 - "Ersentilide was tested in 19 dogs with a healed myocardial infarction (MI) undergoing two minutes of circumflex artery occlusion (CAO) during sub-maximal treadmill exercise. " 10/01/1998 - "Antifibrillatory efficacy of ersentilide, a novel beta-adrenergic and Ikr blocker, in conscious dogs with a healed myocardial infarction." 08/01/1990 - "The antiarrhythmic and antifibrillatory actions of the CK-3579 and sematilide, two new class III antiarrhythmic drugs, administered in a multiple-dose regimen were evaluated in conscious dogs 3-5 days after anterior myocardial infarction. "
2.	Cardiac Arrhythmias (Arrythmia) 10/04/1995 - "Ersentilide is a benzamide derivative that has been found effective in several intact animal models of arrhythmia. "
3.	Disease Progression 09/01/2010 - "Specificity was highest in studies of patients with high grade HE (93 (80-100)%) and where KCC were applied dynamically through the clinical course (88 (78-97)%). "
4.	Myocardial Ischemia (Ischemic Heart Diseases) 10/01/1998 - "Ersentilide lowered heart rate at all levels of exercise and during acute myocardial ischemia. "
5.	Ventricular Tachycardia 08/01/1990 - "Sematilide significantly suppressed the induction of ventricular tachyarrhythmia by programmed electrical stimulation in six of 10 postinfarcted dogs, whereas CK-3579 suppressed the induction of tachyarrhythmia in only two of 10 animals. "

Related Drugs and Biologics

1.	Adrenergic Agents (Adrenergic Drugs)
2.	benzamide
3.	Anti-Arrhythmia Agents
4.	sematilide