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4'-demethylamino-4'-hydroxystaurosporine
structure given in first source; produced by Streptomyces sp. RK-286
Also Known As:
4'-demethylamino-4'-hydroxy-staurosporine; RK 286C; RK-286C; 9,13-Epoxy-1H,9H-diindolo(1,2,3-gh:3',2',1'-lm)pyrrolo(3,4-j)(1,4)benzodiazonin-1-one, 2,3,10,11,12,13-hexahydro-11-hydroxy-10-methoxy-9-methyl-, (9R-(9alpha,10beta,11beta,13alpha))-
Networked:
3
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Heterocyclic Compounds: 198
Alkaloids: 5398
Indole Alkaloids: 200
Staurosporine: 958
4'-demethylamino-4'-hydroxystaurosporine: 3
Fused-Ring Heterocyclic Compounds
2-Ring Heterocyclic Compounds
Indoles: 200
Indole Alkaloids: 200
Staurosporine: 958
4'-demethylamino-4'-hydroxystaurosporine: 3
Carbazoles: 32
Staurosporine: 958
4'-demethylamino-4'-hydroxystaurosporine: 3
Indolizines: 3
Indolizidines: 2
Indole Alkaloids: 200
Staurosporine: 958
4'-demethylamino-4'-hydroxystaurosporine: 3
3-Ring Heterocyclic Compounds
Carbazoles: 32
Staurosporine: 958
4'-demethylamino-4'-hydroxystaurosporine: 3
Related Diseases
1.
Tetraploidy
12/01/1991 - "
The staurosporine analogues, K-252a and RK-286C, were found to cause DNA re-replication in rat diploid fibroblasts (3Y1) without an intervening mitosis, producing tetraploid cells.
"
2.
Acute Erythroblastic Leukemia (Erythroleukemia)
02/01/1990 - "
The inhibitor, RK-286C (4'-demethylamino-4'-hydroxystaurosporine), inhibited the morphological change of K562 cells, a human chronic erythroleukemia cell, induced by phorbol 12,13-dibutylate at the concentration of 3 microM.
"
3.
Blister (Bulla)
02/01/1990 - "
RK-286C, a new inhibitor of protein kinase C, has been found by the bleb-forming assay using K562 cells.
"
Related Drugs and Biologics
1.
Staurosporine
2.
Protein Kinase C
3.
DNA (Deoxyribonucleic Acid)
4.
staurosporine aglycone (K252a)
5.
phorbol