probestin

inhibitor of aminopeptidase M; from Streptomyces azureus MH663-2F6; structure given in first source

Also Known As:

3-amino-2-hydroxy-4-phenylbutanoyl-leucyl-prolyl-proline; L-Proline, 1-(1-(N-(3-amino-2-hydroxy-1-oxo-4-phenylbutyl)-L-leucyl)-L-prolyl)-, (S-(R*,S*))-

Networked: 2 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Peptides: 82426
  - Oligopeptides: 519
    - probestin: 2

Experts

1.	Gali, Hariprasad: 2 articles (09/2013 - 06/2013)
2.	Ihnat, Michael A: 2 articles (09/2013 - 06/2013)
3.	Pathuri, Gopal: 2 articles (09/2013 - 06/2013)
4.	Awasthi, Vibhudutta: 1 article (09/2013)
5.	Hedrick, Andria F: 1 article (09/2013)
6.	Bailey-Downs, Lora C: 1 article (06/2013)
7.	Disch, Bryan C: 1 article (06/2013)
8.	Thorpe, Jessica E: 1 article (06/2013)

Related Diseases

1.	Neoplasms (Cancer) 06/15/2013 - "Results from these studies demonstrate that probestin inhibits the angiogenic activity and tumor growth." 09/15/2013 - "These results collectively demonstrate that (99m)Tc-probestin uptake by tumors and other APN expressing tissues in vivo is specific and validate the use of probestin as a vector for targeting APN in vivo. " 06/15/2013 - "Here, we report probestin synthesis by solid phase peptide synthesis (SPPS) method and evaluated its activity to inhibit angiogenesis using a chicken embryo chorioallantoic membrane (CAM) assay and a CAM tumor xenograft model. " 09/15/2013 - "Here we report results obtained from biodistribution and single photon emission computed tomography (SPECT) imaging studies of a technetium-99m labeled probestin (a potent APN inhibitor) conjugate containing a tripeptide, Asp-DAP-Cys (DAP=2,3-diaminopropionic acid), chelator and a 8-amino-3,6-dioxaoctanoic acid (PEG2) linker conducted in nude mice xenografted with HT-1080 human fibrosarcoma tumors (APN-positive tumors). "
2.	Fibrosarcoma 09/15/2013 - "Here we report results obtained from biodistribution and single photon emission computed tomography (SPECT) imaging studies of a technetium-99m labeled probestin (a potent APN inhibitor) conjugate containing a tripeptide, Asp-DAP-Cys (DAP=2,3-diaminopropionic acid), chelator and a 8-amino-3,6-dioxaoctanoic acid (PEG2) linker conducted in nude mice xenografted with HT-1080 human fibrosarcoma tumors (APN-positive tumors). "

Related Drugs and Biologics

1.	Chelating Agents
2.	Acids
3.	stable plasma protein solution