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2- methyl- 6- (4- methoxyphenyl)- 3,7- dihydroimidazo(1,2- alpha)pyrazin- 3- one (MCLA)

cypridina luciferin analog

Also Known As:

MCLA; 6-(4-methoxyphenyl)imidazo(1,2-a)pyrazin-3(7H)-one

Networked: 20 relevant articles (0 outcomes, 3 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Imidazoles: 150
      - 2-methyl-6-(4-methoxyphenyl)-3,7-dihydroimidazo(1,2-alpha)pyrazin-3-one: 20
  - Pyrazines: 150
    - 2-methyl-6-(4-methoxyphenyl)-3,7-dihydroimidazo(1,2-alpha)pyrazin-3-one: 20

Experts

1.	Bagoly, Zsuzsa: 2 articles (01/2021 - 01/2021)
2.	Chernoff, Neil: 2 articles (01/2021 - 01/2020)
3.	Csiba, László: 2 articles (01/2021 - 01/2021)
4.	Farthing, Amy: 2 articles (01/2021 - 01/2020)
5.	Fekete, István: 2 articles (01/2021 - 01/2021)
6.	Fekete, Klára: 2 articles (01/2021 - 01/2021)
7.	Hill, Donna: 2 articles (01/2021 - 01/2020)
8.	Huang, Hwa: 2 articles (01/2021 - 01/2020)
9.	Lang, Johnsie: 2 articles (01/2021 - 01/2020)
10.	Orbán-Kálmándi, Rita: 2 articles (01/2021 - 01/2021)

Related Diseases

1.	Lmna-Related Congenital Muscular Dystrophy 11/15/2010 - "Here we report that a number of sulfur-containing compounds applied in biochemical and cytological studies are able to suppress MCLA-derived chemiluminescence (MDCL) independent of their capability to scavenge superoxide anion. " 01/01/1995 - "These opsonized zymosans caused not only detectable neutrophil superoxide anion generation evaluated by an MCLA-dependent CL (MDCL) assay, with the order of light emission being IC3Z > IgGZ > C3Z, but also a transient rise of neutrophil [Ca2+]i measured by an aequorin-dependent CL (ADCL) assay. " 01/01/1995 - "Functionally, AD-source eosinophils showed an enhanced MCLA-dependent chemiluminescence (MDCL) responsiveness to the eosinophilopoietic cytokines, with the characteristics that interleukin-5 (IL-5)-induced MDCL responses strongly correlated with EG2+ eosinophil proportions, whereas both IL-3- and granulocyte-macrophage colony-stimulating factor (GM-CSF)-induced MDCL responses rather significantly correlated with the degree of blood eosinophilia. " 01/01/1995 - "Luminol-dependent CL (LDCL) and MCLA-dependent CL (MDCL) in a hypoxanthine (HX)/xanthine oxidase (XOD) system, both of which were completely inhibited by superoxide dismutase, were a linear function of the XOD concentration, with the relationship formula being LDCL = 0.003 x MDCL. "
2.	Ischemia 03/01/2001 - "To investigate the time course of superoxide generation in ischemia-reperfusion in the in-vivo rat lung, the present study used an enhanced chemiluminescence method with 2-methyl-6-[p-methoxyphenyl]-3,7-dihydroimidazo[1, 2-alpha]pyrazin-3-one (MCLA) as a specific probe. " 01/01/1997 - "In order to clarify the time course of superoxide generation in situ during ischemia and reperfusion in the rabbit heart, we used a method of enhanced chemiluminescence (CL) with 2-methyl-6-[p-methoxyphenyl]-3, 7-dihydroimidazo [1, 2-alpha]pyrazin-3-one (MCLA) as a specific probe for detecting superoxide radicals. " 12/01/2002 - "The exact time profile of superoxide generation during anoxia-reoxygenation and ischemia-reperfusion was assessed in the feline cerebral cortex in vivo using a chemiluminescence technique with a probe specific for superoxide, 2-methyl-6-[p-methoxyphenyl]-3,7-dihydroimidazo[1,2-alpha]pyrazin-3-one (MCLA). "
3.	Breast Neoplasms (Breast Cancer) 02/15/2004 - "In this study, we created a mutant CLA-1 (mCLA) that lacked the COOH-terminal tail to determine its potential role in breast cancer cell growth. " 02/15/2004 - "Expression of mCLA inhibited the proliferation of breast cancer cell line MCF-7. "
4.	Stroke (Strokes) 01/01/2021 - "Stroke severity demonstrated a step-wise positive association with cfDNA levels, while a negative association was found with the time to reach 50% lysis (50%CLT) parameter of CLA and mCLA. " 01/01/2021 - "Results: Patients with more severe stroke (NIHSS>10) presented significantly shorter clot lysis times of the mCLA in the presence of DNA and histone as compared to patients with milder stroke [10%CLT: NIHSS 0-10: median 31.5 (IQR: 21.0-40.0) min vs. NIHSS>10: 24 (18-31.0) min, p = 0.032]. "
5.	Pancreatitis 08/01/1995 - "Using a new chemiluminescence probe (2-methyl-6-[p-methoxyphenyl]-3,7-dihydro-imidazol[1,2-1]pyrazin- 3-one; MCLA; a Cypridina luciferin analogue) and a highly sensitive photon counting system, O2- from the pancreatic surface of rats with experimental acute pancreatitis induced by 180 micrograms cerulein/kg was detected. " 03/01/1996 - "Previously, we directly detected pancreatic active oxygen (O2-) production in rats with cerulein-induced pancreatitis by using a supersensitive photon counter and a cypridina luciferin analogue (MCLA) that reacts specifically with O2- by emitting luminescence. " 08/01/1995 - "Superoxide free radical production in the pancreas of rats with cerulein-induced acute pancreatitis was confirmed using MCLA-dependent chemiluminescence. "

Related Drugs and Biologics

1.	Superoxides (Superoxide)
2.	Sulfur
3.	Luciferins
4.	Ceruletide
5.	2- methyl- 6- phenyl- 3,7- dihydroimidazo(1,2- a)pyrazin- 3- one
6.	Hypoxanthine
7.	Anti-Allergic Agents (Antiallergic Agents)
8.	Reactive Oxygen Species (Oxygen Radicals)
9.	Cytokines
10.	Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF)