cruzipain

from epimastigotes of Trypanosoma cruzi; inhibited by L-trans-epoxysuccinylleucylamino(4-guanidino)butane (E-64); shares several of the properties of mammalian cathepsin L; GenBank X54414

Also Known As:

Networked: 141 relevant articles (8 outcomes, 13 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	McKerrow, James H: 11 articles (01/2020 - 11/2007)
2.	Montanari, Carlos A: 7 articles (11/2020 - 01/2013)
3.	Gea, Susana: 7 articles (11/2011 - 01/2002)
4.	Ferreira, Rafaela Salgado: 6 articles (01/2022 - 05/2015)
5.	Leitão, Andrei: 6 articles (11/2020 - 01/2017)
6.	Doyle, Patricia S: 6 articles (01/2013 - 11/2007)
7.	Scharfstein, Julio: 6 articles (01/2011 - 07/2002)
8.	Ferreira, Rafaela S: 5 articles (01/2021 - 07/2010)
9.	Cazorla, Silvia I: 5 articles (01/2016 - 12/2003)
10.	Malchiodi, Emilio L: 5 articles (01/2016 - 12/2003)

Related Diseases

1.	Chagas Disease (American Trypanosomiasis) 01/01/2013 - "Among the best-studied cruzain inhibitors to date is the vinylsulfone K777 (1), which has proven effective in animal models of Chagas' disease. " 07/01/2016 - "The aim of this work was to determine the efficacy of these novel cruzipain inhibitors when administered in a murine model of chronic Chagas disease. " 01/01/2016 - "We have previously reported the efficacy of attenuated Salmonella enterica (S) carrying plasmid encoding cruzipain (SCz) to protect against Trypanosoma cruzi infection. " 01/01/2018 - "Molecular description of α-keto-based inhibitors of cruzain with activity against Chagas disease combining 3D-QSAR studies and molecular dynamics." 03/15/2005 - "Information on the compounds reported here will be useful in the development of new lead compounds as potential therapeutic agents for the treatment of Chagas disease and as biological probes to study the role that cruzain plays in the pathology. "
2.	Infections 01/01/2021 - "serpens recovered from the infection of mature tomatoes showed an increase in the expression of molecules homologous to cruzipain; however, cells showed a smaller size compared to parasites grown in BHI medium. " 09/01/2011 - "Thus cruzain hinders macrophage activation during the early (<60 min) stages of infection, by interruption of the NF-κB P65 mediated signaling pathway. " 11/01/2010 - "Taken together, we believe these results demonstrate for the first time that cruzipain, a single parasite molecule, in the absence of infection, favors oxidative burst in murine cells. " 07/01/2010 - "This phenomenon is not a property of the parasite but of cruzipain itself, because recombinant cruzipain triggers a response similar to that of cruzipain during natural or experimental infection. " 01/01/2002 - "cruzi infection, cruzipain could be used by the parasite to spread inside the host."
3.	Parasitemia 01/01/2017 - "Tc3, cytosolic tryparedoxin peroxidase, cruzipain and TS showed the best outcome after infection in survival level and parasitemia. "
4.	Inflammation (Inflammations) 08/01/2008 - "Studies of the dynamics of inflammation in the subcutaneous model of infection revealed that the balance between cruzipain and angiotensin-converting enzyme, respectively acting as kinin-generating and degrading enzymes, governs extent of DC maturation and TH1 development via the B2R-dependent innate pathway. " 07/01/2009 - "Finally, we will review the results of molecular studies suggesting that parasite-induced inflammation and tissue damage is, at least in part, mediated by the activities of trans-sialidase, mucin-linked lipid anchors (TLR2 ligand) and cruzipain (a kinin-releasing cysteine protease). " 01/01/2011 - "Analyses of the dynamics of inflammation revealed that tissue culture trypomastigotes elicit interstitial oedema in peripheral sites of infection through synergistic activation of toll-like 2 receptors (TLR2) and G-protein-coupled bradykinin receptors, respectively, engaged by tGPI (TLR2 ligand) and kinin peptides (bradykinin B2 receptors (BK(2)R) ligands) proteolytically generated by cruzipain. "
5.	Persistent Infection 07/01/2002 - "Cruzipain-specific serum IgG responses were induced during chronic infection with T. " 04/25/2001 - "In Chagas' disease, the chronic infection caused by Trypanosoma cruzi, structure-functional studies on cysteine proteases were thus far limited to the parasite's major isoform, a cathepsin L-like lysosomal protease designated as cruzipain, cruzain or GP57/51. "

Related Drugs and Biologics

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5.	Phenothiazines
6.	Naphthoquinones
7.	Methylphenazonium Methosulfate
8.	Lactones
9.	Isoquinolines
10.	Hydrazones

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Therapeutics