|1.||Gea, Susana: 7 articles (11/2011 - 04/2002)|
|2.||Scharfstein, Julio: 6 articles (01/2011 - 07/2002)|
|3.||Cazorla, Silvia I: 4 articles (03/2015 - 12/2003)|
|4.||Malchiodi, Emilio L: 4 articles (03/2015 - 12/2003)|
|5.||Scharfstein, J: 4 articles (11/2001 - 06/2000)|
|6.||Guzmán, Carlos A: 3 articles (03/2015 - 04/2008)|
|7.||Couto, Alicia S: 3 articles (09/2014 - 08/2005)|
|8.||Duschak, Vilma G: 3 articles (09/2014 - 08/2005)|
|9.||Ndao, Momar: 3 articles (04/2014 - 12/2010)|
|10.||Pellegrini, Andrea: 3 articles (11/2011 - 11/2004)|
|1.||Chagas Disease (American Trypanosomiasis)
01/01/2015 - "Our data suggest that cruzipain inhibition is an interesting chemotherapeutic approach for Chagas disease not only because of its trypanocidal activity, but also due to the inhibitory effect on TGF-β activation. "
01/01/2015 - "Here, we tested the hypothesis that cruzipain could be an important activator of latent TGF-β and thereby trigger TGF-β-mediated events crucial for the development of Chagas disease. "
09/23/2013 - "Cruzipain (Cz) is the major cystein protease of the protozoan Trypanosoma cruzi , etiological agent of Chagas disease. "
12/15/2010 - "Identification of potent and reversible cruzipain inhibitors for the treatment of Chagas disease is described. "
12/15/2010 - "Identification of potent and reversible cruzipain inhibitors for the treatment of Chagas disease."
11/01/2010 - "Taken together, we believe these results demonstrate for the first time that cruzipain, a single parasite molecule, in the absence of infection, favors oxidative burst in murine cells. "
07/01/2010 - "This phenomenon is not a property of the parasite but of cruzipain itself, because recombinant cruzipain triggers a response similar to that of cruzipain during natural or experimental infection. "
07/01/2010 - "Redirection of the immune response to the functional catalytic domain of the cystein proteinase cruzipain improves protective immunity against Trypanosoma cruzi infection."
09/01/2002 - "Cruzipain, the major cysteinyl proteinase of Trypanosoma cruzi, is expressed by all developmental forms and strains of the parasite and stimulates potent humoral and cellular immune responses during infection in both humans and mice. "
07/01/2002 - "Induction of B- and T-cell responses to cruzipain in the murine model of Trypanosoma cruzi infection."
08/01/2008 - "Studies of the dynamics of inflammation in the subcutaneous model of infection revealed that the balance between cruzipain and angiotensin-converting enzyme, respectively acting as kinin-generating and degrading enzymes, governs extent of DC maturation and TH1 development via the B2R-dependent innate pathway. "
07/01/2009 - "Finally, we will review the results of molecular studies suggesting that parasite-induced inflammation and tissue damage is, at least in part, mediated by the activities of trans-sialidase, mucin-linked lipid anchors (TLR2 ligand) and cruzipain (a kinin-releasing cysteine protease). "
01/01/2011 - "Analyses of the dynamics of inflammation revealed that tissue culture trypomastigotes elicit interstitial oedema in peripheral sites of infection through synergistic activation of toll-like 2 receptors (TLR2) and G-protein-coupled bradykinin receptors, respectively, engaged by tGPI (TLR2 ligand) and kinin peptides (bradykinin B2 receptors (BK(2)R) ligands) proteolytically generated by cruzipain. "
|4.||Visceral Leishmaniasis (Kala Azar)
11/01/2002 - "westermani are cruzipain-like type implies strongly that a new powerful drug for paragonimiasis could be designed and developed if we focus on the exploration of anti-agents against P. "
06/01/2000 - "Antibody responses in serum and cerebrospinal fluid (CSF) samples from patients with active and chronic paragonimiasis and in sera from patients on whom follow-up studies were done after praziquantel treatment were analyzed using antigens of Paragonimus westermani prepared from eggs, metacercariae, juveniles of 4- and 7-week old, adult worms and recombinant protein of 28 kDa cruzipain-like cysteine protease (rPw28CCP). "
|9.||Gentian Violet (Violet, Crystal)
|10.||Coloring Agents (Dyes)
|1.||Drug Therapy (Chemotherapy)