|1.||Durán, Nelson: 6 articles (05/2011 - 04/2003)|
|2.||Haun, Marcela: 4 articles (06/2010 - 04/2003)|
|3.||Justo, Giselle Z: 4 articles (06/2010 - 04/2003)|
|4.||Antonisamy, P: 2 articles (01/2016 - 03/2010)|
|5.||Johnson, Terrance: 2 articles (07/2015 - 12/2014)|
|6.||Mehta, Toral: 2 articles (07/2015 - 12/2014)|
|7.||Duran, Nelson: 2 articles (01/2015 - 12/2006)|
|8.||Antonisamy, Paulrayer: 2 articles (01/2014 - 08/2009)|
|9.||Ignacimuthu, Savarimuthu: 2 articles (01/2014 - 08/2009)|
|10.||Kannan, Ponnusamy: 2 articles (01/2014 - 08/2009)|
09/01/2004 - "Here, we show that violacein causes apoptosis in HL60 leukemic cells but is ineffective in this respect in other types of leukemia cells or in normal human lymphocytes and monocytes. "
09/01/2004 - "Molecular mechanism of violacein-mediated human leukemia cell death."
09/01/2000 - "Violacein is also effective against leukemia and lymphoma cells in culture (IC50 10(-8) M). "
12/01/2006 - "Several studies have shown that violacein, a purple pigment extracted from Chromobacterium violaceum, is capable to induce apoptosis in a variety of cancer cells, including those leukemia cell lines. "
04/22/2003 - "In this work, our aim was to investigate the effectiveness of violacein/beta-cyclodextrin (beta-CD)-containing systems to produce lethal effects in the human promyelocytic leukemia cell line HL60. "
08/01/2009 - "Anti-diarrhoeal and ulcer-protective effects of violacein isolated from Chromobacterium violaceum in Wistar rats."
08/01/2009 - "The results suggested that violacein can be used for the treatment of diarrhoeal and ulcer-related diseases."
03/01/2011 - "Pigments like prodigiosin and shikonin have antitumor activity, while violacein has anti-ulcer and antitumor activity and also acts as an antiprotozoal agent. "
08/01/2009 - "Violacein exhibited ulcer-protective properties against ethanol-induced ulceration in rats with maximal anti-ulcer activity at 40 mg/kg. Violacein also exerted significant anti-enteropooling effects, causing a dose-related inhibitory effect on castor oil-induced enteropooling in rats. "
08/01/2009 - "In the present study the anti-diarrhoeal and ulcer-protective properties of violacein were investigated in Wistar rats using castor oil, magnesium sulphate and ethanol. "
|4.||Ehrlich Tumor Carcinoma
06/07/2010 - "Herein, violacein, a natural indolic pigment extracted from Chromobacterium violaceum, was evaluated for its antitumoral potential against the Ehrlich ascites tumor (EAT) in vivo and in vitro. "
06/07/2010 - "Growth inhibition and pro-apoptotic activity of violacein in Ehrlich ascites tumor."
07/01/2015 - "Additionally, solid tumors examined in the present study displayed differential cellular responses and sensitivities to violacein as observed by morphologically induced cellular changes that contributed to its anti-migratory properties. "
07/01/2015 - "Violacein, a purple pigment produced by Chromobacterium violaceum, was investigated in the present study for its anti-tumor properties in tumor cell lines. "
04/01/2015 - "This study assessed the anti-proliferative activity of violacein in a number of human cancer cell lines under normal and hypoxic conditions. "
12/05/2014 - "These studies could offer a novel venue for violacein in cancer therapy."
12/05/2014 - "Taken together, these studies demonstrate a unique anti-tumor mechanism of action of violacein through reduction of CXCL12/CXCR4 interaction. "
|1.||Ethanol (Ethyl Alcohol)
|3.||Castor Oil (Oil, Castor)
|4.||Reactive Oxygen Species (Oxygen Radicals)
|5.||Caspase 3 (Caspase-3)
|6.||Cytochromes c (Cytochrome c)
|7.||Protein Kinases (Protein Kinase)