violacein

produced by BB-78 strain of Chromobacterium violaceum; involved with quorum sensing

Also Known As:

(3E)-3-(1,2-dihydro-5-(5-hydroxy-1H-indol-3-yl)-2-oxo-3H-pyrrol-3-ylidene)-1,3-dihydro-2H-indol-2-one; 3-(1,2-dihydro-5-(5-hydroxy-1H-indole-3-yl)-2-oxo-3H-pyrrol-3-ylidene)-1,3-dihydro-2H-indole-2-one

Networked: 53 relevant articles (4 outcomes, 15 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Indoles: 200
      - violacein: 53

Experts

1.	Durán, Nelson: 11 articles (01/2022 - 04/2003)
2.	Justo, Giselle Z: 6 articles (01/2022 - 04/2003)
3.	Haun, Marcela: 4 articles (06/2010 - 04/2003)
4.	Ferreira-Halder, Carmen V: 3 articles (01/2022 - 10/2016)
5.	Nakazato, Gerson: 3 articles (08/2021 - 05/2011)
6.	Durán, N: 2 articles (10/2022 - 09/2000)
7.	Pantanella, Fabrizio: 2 articles (04/2022 - 03/2016)
8.	Schippa, Serena: 2 articles (04/2022 - 03/2016)
9.	Wittmann, Christoph: 2 articles (01/2022 - 11/2013)
10.	Brocchi, Marcelo: 2 articles (08/2021 - 12/2019)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2022 - "Taken together, this study provides new insights into the biological activity of violacein against cancer. " 01/01/2022 - "In this study, the anti-cancer activities of the purple compound violacein, initially isolated from Chromobacterium violaceum, were investigated. " 07/01/2015 - "Additionally, solid tumors examined in the present study displayed differential cellular responses and sensitivities to violacein as observed by morphologically induced cellular changes that contributed to its anti-migratory properties. " 07/01/2015 - "Violacein, a purple pigment produced by Chromobacterium violaceum, was investigated in the present study for its anti-tumor properties in tumor cell lines. " 04/01/2015 - "This study assessed the anti-proliferative activity of violacein in a number of human cancer cell lines under normal and hypoxic conditions. "
2.	Leukemia 09/01/2004 - "Here, we show that violacein causes apoptosis in HL60 leukemic cells but is ineffective in this respect in other types of leukemia cells or in normal human lymphocytes and monocytes. " 09/01/2004 - "Molecular mechanism of violacein-mediated human leukemia cell death." 09/01/2000 - "Violacein is also effective against leukemia and lymphoma cells in culture (IC50 10(-8) M). " 12/01/2006 - "Several studies have shown that violacein, a purple pigment extracted from Chromobacterium violaceum, is capable to induce apoptosis in a variety of cancer cells, including those leukemia cell lines. " 04/22/2003 - "In this work, our aim was to investigate the effectiveness of violacein/beta-cyclodextrin (beta-CD)-containing systems to produce lethal effects in the human promyelocytic leukemia cell line HL60. "
3.	Ulcer 08/01/2009 - "Anti-diarrhoeal and ulcer-protective effects of violacein isolated from Chromobacterium violaceum in Wistar rats." 08/01/2009 - "The results suggested that violacein can be used for the treatment of diarrhoeal and ulcer-related diseases." 03/01/2011 - "Pigments like prodigiosin and shikonin have antitumor activity, while violacein has anti-ulcer and antitumor activity and also acts as an antiprotozoal agent. " 08/01/2009 - "Violacein exhibited ulcer-protective properties against ethanol-induced ulceration in rats with maximal anti-ulcer activity at 40 mg/kg. Violacein also exerted significant anti-enteropooling effects, causing a dose-related inhibitory effect on castor oil-induced enteropooling in rats. " 08/01/2009 - "In the present study the anti-diarrhoeal and ulcer-protective properties of violacein were investigated in Wistar rats using castor oil, magnesium sulphate and ethanol. "
4.	Melanoma (Melanoma, Malignant) 08/12/2023 - "Violacein, a natural pigment produced by Chromobacterium violaceum, induces apoptosis in a variety of tumours, including melanoma. " 10/01/2016 - "Furthermore, violacein was able to reduce significantly the invasion capacity of metastatic melanoma cells in 3D culture. " 10/01/2016 - "Violacein induces death of RAS-mutated metastatic melanoma by impairing autophagy process." 10/01/2016 - "In the present study, we demonstrate that violacein diminished the viability of RAS- and RAF-mutated melanoma cells (IC50 value ∼500 nM), and more important, this effect was not abolished after treatment medium removal. " 08/12/2023 - "Violacein improves vemurafenib response in melanoma spheroids."
5.	Glioblastoma (Glioblastoma Multiforme) 03/01/2022 - "Moreover, violacein released from the nanoparticles at 500 μg/mL successfully inhibited the growth of the "superbug" methicillin-resistant Staphylococcus aureus (MRSA) with an IC50 value of 595.8 μg/mL, while it did not prove effective against multi-drug-resistant Escherichia coli at concentrations of 10-1000 μg/mL. Finally, a concentration of 500 μg/mL of drug loaded magnetic nanoparticles induced an over 80% growth inhibition of glioblastoma and melanoma cancer cell lines with IC50 values of 221.30 and 201.60 μg/mL, respectively. " 07/01/2015 - "The anti-malignant properties of violacein in the present study were further demonstrated by its inhibitory effects on brain tumor cell migration, specifically glioblastomas, one of the most invasive and therapeutically resistant neoplasms in the clinic. "

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5.	Matrix Metalloproteinase 2 (Gelatinase A)
6.	Magnesium
7.	Lipase (Acid Lipase)
8.	Castor Oil (Oil, Castor)
9.	Antineoplastic Agents (Antineoplastics)
10.	lissamine rhodamine B (sulforhodamine B)

Related Therapies and Procedures

1.	Therapeutics
2.	Aftercare (After-Treatment)
3.	Precision Medicine
4.	Ligation