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2',3'-dideoxyuridine-5'-triphosphate

inhibits HIV reverse transcriptase & has potent DNA chain termination activity

Also Known As:

ddUTP; Uridine 5'-(tetrahydrogen triphosphate), 2',3'-dideoxy-

Networked: 4 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrimidines: 510
    - Pyrimidine Nucleotides: 48
      - Uracil Nucleotides: 40
        2',3'-dideoxyuridine-5'-triphosphate: 4
Nucleic Acids, Nucleotides, and Nucleosides: 1
- Nucleotides: 15763

Experts

1.	Kallajoki, Markku: 1 article (12/2005)
2.	Kentala, Erkki: 1 article (12/2005)
3.	Kiss, Jan: 1 article (12/2005)
4.	Kytö, Ville: 1 article (12/2005)
5.	Malmberg, Markus: 1 article (12/2005)
6.	Saraste, Antti: 1 article (12/2005)
7.	Savunen, Timo: 1 article (12/2005)
8.	Vähäsilta, Tommi: 1 article (12/2005)

Related Diseases

1.	Systemic Lupus Erythematosus (Libman-Sacks Disease) 08/01/1993 - "DNA typing for HLA-DPB1-alleles in German patients with systemic lupus erythematosus using the polymerase chain reaction and DIG-ddUTP-labelled oligonucleotide probes. " 01/01/1993 - "We have investigated the DNA polymorphism for the DQA1 promoter region (QAP) and HLA-class II DRB1, DQA1, and DQB1 genes in 178 central European patients with Systemic lupus erythematosus (SLE) using polymerase chain reaction and Dig-ddUTP labeled oligonucleotides. " 08/01/1993 - "Genomic DNA of 178 German Caucasian patients with systemic lupus erythematosus are studied for HLA-DP locus by using PCR and DIG-ddUTP-labelled oligonucleotide probes. "
2.	beta-Thalassemia (Cooley's Anemia) 01/01/1991 - "Detection of beta-thalassemia mutations by ASO hybridization of PCR amplified DNA with digoxigenin ddUTP labeled oligonucleotides."
3.	Ischemia 12/01/2005 - "Cardiomyocyte apoptosis was measured using the terminal transferase mediated ddUTP nick end-labeling (TUNEL) assay and immunohistochemical (IHC) staining for active caspase-3 in myocardial biopsies obtained before ischemia and after 90 minutes of reperfusion. "

Related Drugs and Biologics

1.	DNA (Deoxyribonucleic Acid)
2.	Oligonucleotides
3.	Caspase 3 (Caspase-3)
4.	Oligonucleotide Probes
5.	Transferases
6.	HLA-DP Antigens (HLA-DP)
7.	Digoxigenin