09/01/1989 - "AHR-12234 was also effective in ablating ouabain-induced ventricular tachycardias in anesthetized dogs following an i.v. dose of 5 mg/kg. These results indicate that the structurally novel AHR-12234 is effective against arrhythmias due to abnormal automaticity, triggered activity and reentry."
|3.||Cardiac Arrhythmias (Arrythmia)
09/01/1989 - "The duration of action of oral AHR-12234 against this arrhythmia persisted for 24 hr. In the 1-day infarcted conscious dogs, AHR-12234 administered either i.v. (effective doses: 3.8 +/- 0.9 mg/kg) or orally (20 mg/kg), effectively converted the ventricular arrhythmia into sinus rhythm. "
09/01/1989 - "In the conscious dog model for reentrant atrial tachycardia, i.v. (effective doses: 12.3 +/- 4.2 mg/kg), or oral (20 to 60 mg/kg) administration of AHR-12234 prolonged the cycle length of the tachycardia and terminated the arrhythmia. "
|1.||Ouabain (G Strophanthin)