2,3- dioxo- 6- nitro- 7- sulfamoylbenzo(f)quinoxaline (NBQX)

01/01/2018 - "Further, brief treatment with the AMPAR antagonist NBQX following seizures, prior to the CP, prevents synapse unsilencing and permits subsequent A1 plasticity. "
01/01/2016 - "NBQX was sufficient to decrease seizures through increasing the latency to seizures, decrease the duration of seizure onset, and reduce the scores for the severity of seizures. "
01/01/2016 - "We found that only NBQX had an effect on acute seizure development, resulting in a significantly higher number of mice experiencing seizures, an increase in the number of seizures per mouse, a greater cumulative seizure score per mouse and a significantly higher mortality rate among the mice. "
11/01/2013 - "Brief NBQX administration during the 48 h postseizure in P10 Long-Evans rats suppresses transient mTOR pathway activation and attenuates spontaneous recurrent seizures, social preference deficits, and mossy fiber sprouting observed in vehicle-treated adult rats after early life seizures. "
11/01/2013 - "Although spontaneous recurrent seizures increased in adulthood in HS + V rats compared to controls (3.22 ± 1 seizures/h; p = 0.03), NBQX significantly attenuated later-life seizures (0.14 ± 0.1 seizures/h; p = 0.046). "

01/01/1996 - "In the third study referred here, two groups of ischemic rats were given NBQX (30 mg/kg x 3) immediately after ischemia. "
08/01/2000 - "Gray matter damage and neuronal loss in the ventral horn were evident after ischemia, but no difference was noted between the saline and NBQX groups. "
02/01/1997 - "We found that administration of NBQX in generally accepted dosages can protect the rapidly dying SS neurons in hilus from only brief episodes of ischemia."
02/01/1997 - "After 10 and 12 min of ischemia, NBQX had no significant effects on loss of SS neurons in the dentate hilus. "
02/01/1997 - "After 8 min of ischemia, NBQX prevented loss of hilar SS neurons. "

03/17/2000 - "By contrast, neither the D-AP5 nor the NBQX produced a statistically significant change in the thermal allodynia behavior in either forelimbs or hindlimbs in the hemisected group. "
08/01/1996 - "The mechanical allodynia was only relieved by NBQX at a sedative dose. "
09/20/2011 - "Thermal hyperalgesia induced by IL-1β (30pg) was completely prevented by the coadministration of CPP (3ng) but unaffected by NBQX (250ng). "
01/01/2004 - "When the same injection was given after L5 SNL-induced mechanical hyperalgesia had been established, MK-801 reversed the PWT reduction for 30-75 min, whereas NBQX, DL-AP3, or APDC had no effect. "
09/01/2003 - "Secondary mechanical hyperalgesia after gastrocnemius incision was dose-dependently blocked by NBQX but was only marginally affected by AP5 or MK-801. "

10/01/1993 - "Neuroprotection with NBQX and thrombolysis with rt-PA in rat embolic stroke."
11/01/1993 - "Enhancing the efficacy of thrombolysis by AMPA receptor blockade with NBQX in a rat embolic stroke model."
10/01/1993 - "The efficacy of delayed thrombolysis with recombinant tissue plasminogen activator was tested in combination with the ischaemic protecting drug NBQX in an embolic stroke model. "

10/18/2011 - "In conclusion, transplants of NRP/GRP combined with NBQX promote recovery of micturition function following spinal cord injury, likely through increased neuroprotection."
08/01/2002 - "NBQX treatment improves mitochondrial function and reduces oxidative events after spinal cord injury."
01/01/1999 - "Thus, the chronic effects of NBQX in reducing white matter loss after spinal cord injury appear to be attributable to the reduction of acute pathology and may be mediated through the protection of glia, particularly oligodendrocytes."
01/01/1999 - "2,3-Dihydroxy-6-nitro-7-sulfamoyl-benzo(f)quinoxaline reduces glial loss and acute white matter pathology after experimental spinal cord contusion."
03/01/2000 - "We found that locally administered MK-801 or NBQX 15 min after spinal cord injury attenuated the amplitude, delayed the latency of sensory evoked potentials and increased the sensory conduction time across the injury site, but did not improve blood flow during the 4-h period of observation. "