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LY 181984
Also Known As:
LY-181984; MPCU; N-(4-methylphenylsulfonyl)-N'-(4-chlorophenyl)urea
Networked:
6
relevant articles (
0
outcomes,
2
trials/studies)
Bio-Agent Context: Research Results
Organic Chemicals: 133
Amides: 2428
Urea: 15015
Sulfonylurea Compounds: 35
LY 181984: 6
Sulfur Compounds: 278
Sulfones: 534
Sulfonylurea Compounds: 35
LY 181984: 6
Related Diseases
1.
Neoplasms (Cancer)
06/01/1997 - "
In this study, sera from tumor-bearing and control rats, cancer patients, normal volunteers, and patients with diseases other than cancer were collected and assayed for a cancer-specific form of NADH oxidase responsive to the antitumor sulfonylurea N-(4-methylphenylsulfonyl)-N'-(4-chlorophenyl)urea (LY181984).
"
05/26/1999 - "
Activities were inhibited competitively by the cancer cell-specific NADH oxidase inhibitors, capsaicin and the antitumor sulfonylurea N-(4-methylphenylsulfonyl)-N'-(4-chlorophenyl)urea (LY181984).
"
06/01/1997 - "
Our laboratory has described an NADH oxidase activity at the external surface of plasma membrane vesicles from tumor cells where inhibition by an antitumor sulfonylurea, N-(4-methylphenylsulfonyl)-N'-(4-chlorophenyl)urea (LY181984), and by the vanilloid, capsaicin (8-methyl-N-vanillyl-6-noneamide) correlated with inhibition of growth.
"
02/01/1990 - "
N-(4-Methylphenylsulfonyl)-N'-(4-chlorophenyl)urea (MPCU) is a new agent that exhibits high therapeutic activity against human and rodent tumor models.
"
2.
Colonic Neoplasms (Colon Cancer)
01/01/1991 - "
In a human colon adenocarcinoma cell line, GC3/C1, the initial rate of uptake of [3H]MPCU (2.4 microM) was increased by 4.5-fold as pH(e) was reduced from 7.4 to 6.5.
"
04/01/1990 - "
The cellular pharmacology of N-(4-methylphenylsulfonyl)-N'-(4-chlorophenyl)-urea (MPCU) has been examined in a cloned line of GC3 human colon adenocarcinoma cells.
"
02/01/1990 - "
Evidence for mitochondrial localization of N-(4-methylphenylsulfonyl)-N'-(4-chlorophenyl)urea in human colon adenocarcinoma cells.
"
02/01/1990 - "
Initial studies indicated that in vitro [3H]MPCU was concentrated 4- to 6-fold in GC3/c1 human colon adenocarcinoma cells in an azide-sensitive manner.
"
Related Drugs and Biologics
1.
NADH oxidase
2.
Azides
3.
Capsaicin (Zostrix)
4.
LY 181984