N- (4- ((3- (2,4- diamino- 1,6- dihydro- 6- oxo- 5- pyrimidinyl)propyl)amino)benzoyl)glutamic acid

RN & structure given in first source; inhibitor of glycinamide ribonucleotide transformylase and aminoimidazole ribonucleotide transformylase; an anti-purine drug

Also Known As:

5-DACTHF; 5-deazacyclotetrahydrofolate; 543U76

Networked: 1 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Pteridines: 147
      - Pterins: 160
        Folic Acid: 19425
        Tetrahydrofolates: 8
        N-(4-((3-(2,4-diamino-1,6-dihydro-6-oxo-5-pyrimidinyl)propyl)amino)benzoyl)glutamic acid: 1
Enzymes and Coenzymes: 1
- Coenzymes: 558
  - Tetrahydrofolates: 8
    - N-(4-((3-(2,4-diamino-1,6-dihydro-6-oxo-5-pyrimidinyl)propyl)amino)benzoyl)glutamic acid: 1

Related Diseases

1.	Neoplasms (Cancer) 03/15/1994 - "The spheroid studies were extended to in vivo studies examining the effects of 5-DACTHF on established WiDr and colon 38 tumors. " 03/15/1994 - "The results showed that, in contrast to melphalan, which produced cures and tumor regressions, 5-DACTHF produced reversible growth inhibition with no significant regression of tumors. "

Related Drugs and Biologics

1.	Melphalan (Alkeran)