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Ro 31-6930
potassium channel opener
Also Known As:
2-(6-cyano-2,2-dimethyl-2H-1-benzopyran-4-yl)pyridine-1-oxide; Ro-31-6930
Networked:
4
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Heterocyclic Compounds: 198
1-Ring Heterocyclic Compounds
Pyrans: 130
Benzopyrans: 195
Ro 31-6930: 4
Pyridines: 88
Ro 31-6930: 4
Fused-Ring Heterocyclic Compounds
2-Ring Heterocyclic Compounds
Benzopyrans: 195
Ro 31-6930: 4
Experts
1.
MacKenzie, I
: 1 article (05/2001)
2.
Northover, B J
: 1 article (05/2001)
3.
Workman, A J
: 1 article (05/2001)
Related Diseases
1.
Tachycardia (Tachyarrhythmias)
08/21/1990 - "
The hypotensive effects of Ro 31-6930 and cromakalim were accompanied by reflex tachycardia.
"
02/01/1990 - "
The tachycardia evoked by Ro 31-6930 and cromakalim was of shorter duration than the antihypertensive effect of either agent.
"
2.
Bronchial Spasm
01/01/1991 - "
Ro 31-6930 relaxed isolated tracheal muscle from sensitised guinea-pigs which had been contracted by ovalbumin and was equipotent with salmeterol in inhibiting antigen-induced bronchospasm in anaesthetised, sensitised guinea-pigs.
"
3.
Asthma (Bronchial Asthma)
01/01/1991 - "
In view of the protective activity of Ro 31-6930 against antigen challenge in the sensitised guinea-pig and its potency in relation to other bronchodilators, it is considered that compounds which relax airway smooth muscle by the opening of plasmalemmal potassium channels may have a role in the treatment of asthma.
"
4.
Cardiac Arrhythmias (Arrythmia)
05/04/2001 - "
However, these data highlight the potential harm these drugs may cause, since a higher concentration of Ro 31-6930 caused marked shortening of action potentials and significant pro-arrhythmia during ischaemia.
"
Related Drugs and Biologics
1.
Cromakalim (Levcromakalim)
2.
Potassium Channels (Potassium Channel)
3.
Ovalbumin
4.
Bronchodilator Agents (Bronchodilators)
5.
Antihypertensive Agents (Antihypertensives)
6.
Antigens
7.
Salmeterol Xinafoate (Serevent)