aloperine

07/01/2019 - "Our group found Aloperine has protective effects on monocroline-induced pulmonary hypertension in rats by inhibiting oxidative stress in previous researches. "
07/01/2019 - "In summary, these results suggested that Aloperine negatively regulated nuclear factor-κB signaling pathway activity to exert protective effects on PAH and suppressed HPASMCs proliferation therefore has a potential value in the treatment of pulmonary hypertension by negatively modulating pulmonary vascular remodeling."
05/01/2017 - "Protective effects of aloperine on monocrotaline-induced pulmonary hypertension in rats."
10/01/2023 - "Previous studies have reported the beneficial role of Aloperine (ALO), an active vasodilator purified from the seeds and leaves of the herbal plant Sophora alopecuroides L., on experimental pulmonary hypertension (PH); however, detailed mechanisms remain unclear. "
10/01/2023 - "Aloperine protects pulmonary hypertension via triggering PPARγ signaling and inhibiting calcium regulatory pathway in pulmonary arterial smooth muscle cells."

03/15/2015 - "A U266 xenograft tumor model and 5T33 MM cells recapitulated the antitumor efficacy of aloperine, and the animals displayed excellent tolerance of the drug and few adverse effects. "
01/01/2021 - "The up-regulation of circNSUN2 offset the inhibitory effect of Aloperine on cancer cells. "
01/01/2020 - "Accumulating evidence suggests that aloperine possesses multiple pharmacological activities and holds a promising potential in clinical conditions including skin hyper-sensitivity, tumor and inflammatory disorders etc.; however, the current knowledge on aloperine is interspersed and needs to be summarized. "
05/01/2011 - "These results suggest that aloperine may be a novel contributor to the anti-cancer properties of SF."
12/01/2021 - "These results provided the powerful information for cancer immunotherapy of aloperine derivatives with unique endocyclic skeleton by targeting PD-L1 to activate immune cells to kill cancer cells."

01/01/2017 - "The present study aimed to examine the molecular mechanisms underlying aloperine-mediated colitis protection. "
01/01/2022 - "Previously, our group has reported that the generation of induced Treg was promoted by aloperine treatment in a mouse colitis model. "
01/01/2017 - "In conclusion, aloperine regulates inflammatory responses in colitis by inhibiting the PI3K/Akt/mTOR signaling in a PP2A-dependent manner."
01/01/2017 - "In addition, aloperine regulated T-cell proportions and promoted Foxp3 expression in the spleens and mesenteric lymph nodes of DSS-induced colitis mice and in the spleens of the Foxp3GFP mice. "
01/01/2017 - "Aloperine Protects Mice against DSS-Induced Colitis by PP2A-Mediated PI3K/Akt/mTOR Signaling Suppression."

01/01/2022 - "Aloperine Ameliorates IMQ-Induced Psoriasis by Attenuating Th17 Differentiation and Facilitating Their Conversion to Treg."
01/01/2022 - "Collectively, our study supported that aloperine possesses the capacity to affect Th17 differentiation and modulates Th17/Treg balance, thereby alleviating imiquimod (IMQ)-induced psoriasis in mice."
01/01/2022 - "Based on our results, psoriasis, a Th17 dominant skin disease, is selected to explore the potential therapeutic effect of aloperine in vivo. "

07/01/2019 - "However, the anti-inflammation effects of Aloperine on PAH remain unclear. "
12/01/2018 - "To explore the effects of aloperine (ALO) on allergic airway inflammation, we investigated whether its mechanism is related with NF-κB, MAPK, and Nrf2/HO-1 signaling pathways. "
12/01/2018 - "Aloperine suppresses allergic airway inflammation through NF-κB, MAPK, and Nrf2/HO-1 signaling pathways in mice."
12/01/2020 - "The protective effects of aloperine against ox-LDL-induced endothelial dysfunction and inflammation in HUVECs."
01/01/2017 - "Aloperine also effectively attenuated DSS-induced intestinal inflammation based on the pathological score and myeloperoxidase expression and activity in colon tissues. "