Win 57273

bactericidal for Legionella pneumophila

Also Known As:

1-cyclopropyl-7-(2,6-dimethyl-4-pyridinyl)-6-fluoro-1,4-dihydro-4-oxo-3-quinolonecarboxylic acid; Win-57273; 3-Quinolinecarboxylic acid, 1-cyclopropyl-7-(2,6-dimethyl-4-pyridinyl)-6-fluoro-1,4-dihydro-4-oxo-

Networked: 4 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Quinolines: 146
      - Quinolones: 2938
        Fluoroquinolones: 5348
        Win 57273: 4

Related Diseases

1.	Infections 07/01/1990 - "Further testing is necessary to establish if the effectiveness of WIN 57273 is maintained in vivo, first in animals and then in humans with infections caused by methicillin-susceptible and -resistant strains of S. " 10/01/1992 - "The activities of the fluoroquinolone WIN-57273, 14-OH clarithromycin (a human metabolite of clarithromycin), and minocycline against two virulent strains of Mycobacterium avium complex were evaluated in a model of intracellular infection and compared with that of clarithromycin. "
2.	Gram-Positive Bacterial Infections 04/01/1990 - "WIN 57273 was significantly more potent than ciprofloxacin in treating gram-positive bacterial infections (2- to 20-fold) but was significantly less effective at treating gram-negative bacterial infections (30- to 300-fold)."
3.	Gram-Negative Bacterial Infections 04/01/1990 - "WIN 57273 was significantly more potent than ciprofloxacin in treating gram-positive bacterial infections (2- to 20-fold) but was significantly less effective at treating gram-negative bacterial infections (30- to 300-fold)."
4.	Pneumococcal Meningitis (Streptococcus pneumoniae Meningitis) 03/01/1995 - "Using a rabbit model of pneumococcal meningitis, we compared the pharmacokinetics and bactericidal activities in cerebrospinal fluid (CSF) of older (ciprofloxacin, ofloxacin) and newer (levofloxacin, temafloxacin, CP-116,517, and Win 57273) quinolones with those of the beta-lactam ceftriaxone. "

Related Drugs and Biologics

1.	Ciprofloxacin (Cipro)
2.	Levofloxacin (Levaquin)
3.	beta-Lactams
4.	Fluoroquinolones
5.	Clarithromycin (Biaxin)
6.	Quinolones
7.	Ofloxacin (Ofloxacine)
8.	Minocycline (Cyclops)
9.	Methicillin (Metin)
10.	Ceftriaxone (Ceftriaxon)