neurolysin

RefSeq NM_029447 (mouse)

Also Known As:

endopeptidase 24.16; endopeptidase 3.4.24.16; neurolysin, mouse; neurotensin endopeptidase; neurotensin-degrading neutral metalloendopeptidase; oligopeptidase M

Networked: 21 relevant articles (0 outcomes, 4 trials/studies)

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Hydrolases: 2166
    - Peptide Hydrolases: 23957
      - Metalloproteases: 8276
        Metalloendopeptidases: 70
        neurolysin: 21
      - Endopeptidases: 633
        Metalloendopeptidases: 70
        neurolysin: 21

Experts

1.	Karamyan, Vardan T: 8 articles (07/2022 - 04/2014)
2.	Abbruscato, Thomas J: 5 articles (07/2022 - 04/2014)
3.	Esfahani, Shiva Hadi: 3 articles (07/2022 - 01/2022)
4.	Trippier, Paul C: 3 articles (07/2022 - 01/2022)
5.	Rashid, Mamoon: 3 articles (01/2020 - 04/2014)
6.	Nozohouri, Saeideh: 2 articles (07/2022 - 01/2022)
7.	Rahman, Md Shafikur: 2 articles (07/2022 - 01/2022)
8.	Villalba, Heidi: 2 articles (07/2022 - 01/2020)
9.	Zhang, Yong: 2 articles (07/2022 - 01/2022)
10.	Kocot, Joanna: 2 articles (01/2022 - 01/2020)

Related Diseases

1.	Stroke (Strokes) 04/01/2014 - "This study also documents sustained functional up-regulation of neurolysin in frontoparietal cortical membranes for at least 7 days after stroke, which appears not to be transcriptionally or translationally regulated, but rather depends on translocation of cytosolic neurolysin to the membranes and mitochondria. " 10/13/2023 - "There is growing interest in seeking pharmacological activation of neurolysin (Nln) for stroke treatment. " 04/01/2014 - "Experimental stroke: neurolysin back on stage." 10/13/2023 - "Discovery of the Next Generation of Non-peptidomimetic Neurolysin Activators with High Blood-Brain Barrier Permeability: a Pharmacokinetics Study in Healthy and Stroke Animals." 07/01/2022 - "In-Vivo and Ex-Vivo Brain Uptake Studies of Peptidomimetic Neurolysin Activators in Healthy and Stroke Animals."
2.	Middle Cerebral Artery Infarction (Middle Cerebral Artery Syndrome) 04/01/2014 - "In this study, we provide evidence for the first time that membrane-bound endopeptidase neurolysin is up-regulated in different parts of mouse brain affected by focal ischemia-reperfusion in a middle cerebral artery occlusion model of stroke. "
3.	Ischemia 04/01/2014 - "In this study, we provide evidence for the first time that membrane-bound endopeptidase neurolysin is up-regulated in different parts of mouse brain affected by focal ischemia-reperfusion in a middle cerebral artery occlusion model of stroke. "
4.	Brain Ischemia (Cerebral Ischemia) 01/01/2020 - "Previous studies documented up-regulation of peptidase neurolysin (Nln) after brain ischemia, however, the significance of Nln function in the post-stroke brain remained unknown. "
5.	Ischemic Stroke 01/01/2022 - "Small molecule neurolysin activators, potential multi-mechanism agents for ischemic stroke therapy." 01/01/2020 - "Peptidase neurolysin functions to preserve the brain after ischemic stroke in male mice." 01/01/2022 - "Modulating peptidase neurolysin (Nln) has been identified as a potential cerebroprotective target for the development of therapeutics for ischemic stroke. " 07/01/2022 - "Neurolysin (Nln) is a peptidase that functions to preserve the brain following ischemic stroke by hydrolyzing various neuropeptides. " 01/01/2021 - "In this focused review, peptidase neurolysin (Nln) and its extracellular peptide substrates are briefly discussed in relation to pathophysiology of ischemic stroke. "

Related Drugs and Biologics

1.	Peptidomimetics
2.	Peptide Hydrolases (Proteases)
3.	Endopeptidases
4.	Peptides (Polypeptides)
5.	Neurotensin
6.	Proteins (Proteins, Gene)
7.	Enzymes
8.	hemopressin
9.	thimet oligopeptidase (endo-oligopeptidase)
10.	Metalloproteases (Metalloproteinases)

Related Therapies and Procedures

1.	Therapeutics