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N-desmethyltoremifene

metabolite of toremifene; structure given in first source; RN given refers to (Z)-isomer

Also Known As:

N-demethyltoremifene; N-desmethyltoremifene, (E)-isomer

Networked: 3 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Aromatic Hydrocarbons: 291
      - Benzene Derivatives: 17
        Benzylidene Compounds: 10
        Stilbenes: 657
        Tamoxifen: 14288
        N-desmethyltoremifene: 3

Experts

1.	Noguchi, S: 1 article (02/2000)
2.	Shiba, E: 1 article (02/2000)
3.	Taguchi, T: 1 article (02/2000)
4.	Tsukamoto, F: 1 article (02/2000)
5.	Watanabe, T: 1 article (02/2000)

Related Diseases

1.	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 01/01/1998 - "As part of a translational phase II trial investigating the efficacy and potential molecular mechanism of high-dose toremifene as a cisplatin modulator in metastatic non-small-cell lung cancer, plasma concentrations of toremifene and its active metabolite N-desmethyltoremifene were measured to determine whether targeted levels could be achieved clinically. "
2.	Neoplasms (Cancer) 01/01/1997 - "The concentrations of TOR and its metabolite N-demethyltoremifene were highest in lung tissue, but the values measured in tumor specimens were also well above the respective concentrations detected in serum samples. "
3.	Breast Neoplasms (Breast Cancer) 02/01/2000 - "[Plasma concentrations of toremifene citrate and N-desmethyltoremifene in postmenopausal patients with breast cancer--comparison of 120 mg of toremifene citrate administered once a day and divided into 3 separate doses (t.i.d.)]."

Related Drugs and Biologics

1.	Toremifene (Fareston)
2.	Cisplatin (Platino)