Leu(31)-Pro(34)- neuropeptide Y (NY-LP)

specific Y1 receptor agonist

Also Known As:

NY-LP; neuropeptide Y, Leu(31)-Pro(34)-; (Leu(31),Pro(34))NPY; 31-Leu-34-Pro-neuropeptide Y; NPY(Leu(31),Pro(34)); neuropeptide Y, leucyl(31)-proline(34)-

Networked: 5 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Nerve Tissue Proteins: 2
    - Neuropeptides: 6772
      - Neuropeptide Y: 2712
        Leu(31)-Pro(34)- neuropeptide Y: 5
- Peptides: 82426
  - Neuropeptides: 6772
    - Neuropeptide Y: 2712
      - Leu(31)-Pro(34)- neuropeptide Y: 5

Experts

1.	Chen, W: 1 article (01/2014)
2.	Corder, G F: 1 article (01/2014)
3.	Fu, W: 1 article (01/2014)
4.	Kuphal, K E: 1 article (01/2014)
5.	Marvizon, J C: 1 article (01/2014)
6.	McCarson, K E: 1 article (01/2014)
7.	Stiller, C-O: 1 article (01/2014)
8.	Taylor, B K: 1 article (01/2014)
9.	Urban, J H: 1 article (01/2014)
10.	Winter, M K: 1 article (01/2014)

Related Diseases

1.	Hyperalgesia 08/01/2009 - "However, co-administration of NPY or [Leu(31),Pro(34)]-NPY prevented the development of tolerance and withdrawal hyperalgesia. " 08/01/2009 - "In acute study, intracerebroventricular (icv) administration of morphine, NPY or NPY Y1/Y5 receptors agonist [Leu(31),Pro(34)]-NPY produced antinociception, whereas selective NPY Y1 receptors antagonist BIBP3226 caused hyperalgesia. "
2.	Stroke (Strokes) 04/15/2002 - "In a rat endovascular middle cerebral artery occlusion (MCAO) stroke model, we previously showed that intracerebroventricular (ICV) injection of neuropeptide Y (NPY) or an Y1 receptor agonist, [Leu(31),Pro(34)]-NPY, increased the infarct volume, that an Y1 receptor antagonist, BIBP3226, reduced the infarct volume, and that an Y2 receptor agonist, NPY3-36, had no effect. "
3.	Middle Cerebral Artery Infarction (Middle Cerebral Artery Syndrome) 04/15/2002 - "In a rat endovascular middle cerebral artery occlusion (MCAO) stroke model, we previously showed that intracerebroventricular (ICV) injection of neuropeptide Y (NPY) or an Y1 receptor agonist, [Leu(31),Pro(34)]-NPY, increased the infarct volume, that an Y1 receptor antagonist, BIBP3226, reduced the infarct volume, and that an Y2 receptor agonist, NPY3-36, had no effect. "
4.	Pain (Aches) 01/03/2014 - "In dorsal horn neurons, Y1 receptors were extensively expressed and this may have masked the detection of terminal co-localization with CGRP or SP. To determine whether the pain inhibitory actions of Y1 receptors are enhanced by inflammation, we administered [Leu(31), Pro(34)]-NPY after intraplantar injection of complete Freund's adjuvant (CFA) in rat. "
5.	Lordosis 10/01/1996 - "In contrast, the NPY Y1 agonist (Leu(31)Pro(34)) NPY significantly facilitated lordosis in ovx EB- and P-treated females. "

Related Drugs and Biologics

1.	BIBP 3226
2.	Morphine (MS Contin)
3.	Neuropeptide Y
4.	5-Hydroxytryptophan (5 Hydroxytryptophan)
5.	Freund's Adjuvant
6.	BIIE 0246