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SQ 31765
structure given in first source
Also Known As:
3-(acetyloxy)-1-(2-(dimethylamino)ethyl)-1,3,4,5-tetrahydro-4-(4-methoxyphenyl)-6-(trifluromethyl)-2H-1-benzazepine-2-one; SQ 31,765; SQ 32,189; SQ 32189; SQ-31,765; SQ-31765; SQ-32,189
Networked:
1
relevant articles (
1
outcomes,
0
trials/studies)
Relationship Network
Bio-Agent Context: Research Results
Heterocyclic Compounds: 198
Fused-Ring Heterocyclic Compounds
2-Ring Heterocyclic Compounds
Benzazepines: 5
SQ 31765: 1
Related Diseases
1.
Coronary Stenosis (Coronary Artery Stenosis)
12/01/1989 - "
Left anterior descending coronary artery stenosis during atrial pacing resulted in a significant reduction in subendocardial flow in all groups before drug infusion (41 +/- 7, 44 +/- 7 and 35 +/- 9 ml/min/100 g for saline, SQ 31,765 and SQ 32,189, respectively) and treatment with SQ 31,765 did not affect this flow.
"
2.
Stable Angina
12/01/1989 - "
The anti-ischemic effects of SQ 31,765 or its relatively inactive enantiomer SQ 32,189 (to test for effects not related to calcium channel blockade) were determined in a model of stable angina.
"
3.
Ischemia
12/01/1989 - "
Thus, SQ 31,765 can reduce the severity of ischemia in a manner which is independent of changes in myocardial blood flow or hemodynamic alterations.
"
12/01/1989 - "
Anesthetized dogs were given saline (n = 6), SQ 31,765 (n = 6; 0.2 mg/kg) or SQ 32,189 (n = 6; 0.2 mg/kg) i.v. 10 min before ischemia.
"
Related Drugs and Biologics
1.
SQ 31765
2.
Calcium Channels (Calcium Channel)