CI 959

antiallergy compound; inhibits thromboxanes

Also Known As:

5-methoxy-3-(1-methylethoxy)-N-1H-tetrazol-5-yl-benzo(b)thiophene-2-carboxamide; CI-959; Benzo(b)thiophene-2-carboxamide, 5-methoxy-3-(1-methylethoxy)-N-1H-tetrazol-5-yl-, monosodium salt

Networked: 7 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Tetrazoles: 14
      - CI 959: 7
  - Thiophenes: 257
    - CI 959: 7
Organic Chemicals: 133
- Sulfur Compounds: 278
  - Thiophenes: 257
    - CI 959: 7

Experts

1.	Andersen, Ingelise: 1 article (10/2019)
2.	Christensen, Lisa B: 1 article (10/2019)
3.	Danielsen, Bo: 1 article (10/2019)
4.	Diderichsen, Finn: 1 article (10/2019)
5.	Hach, Maria: 1 article (10/2019)
6.	Hvidtfeldt, Ulla A: 1 article (10/2019)
7.	Lange, Theis: 1 article (10/2019)
8.	Osler, Merete: 1 article (10/2019)
9.	Prescott, Eva: 1 article (10/2019)

Related Diseases

1.	Myocardial Infarction 10/01/1992 - "Reduction of canine myocardial infarct size by CI-959, an inhibitor of inflammatory cell activation." 10/01/1992 - "The results of this study show that CI-959 significantly reduces the myocardial infarct size without causing scar thinning, which might lead to ventricular aneurysm, and suggests the most likely mechanism for its beneficial action is the prevention of formation of toxic oxygen radicals." 10/01/1992 - "CI-959, a cell-activation inhibitor that prevents the formation of oxygen-derived free radicals by inflammatory cells, was studied to determine its effects on myocardial infarct size and subsequent scar formation in dogs. "
2.	Cicatrix (Scar) 10/01/1992 - "The scar thickness, measured after a 6-week recovery period in 9 animals treated with CI-959, was not significantly reduced in comparison with 11 controls. " 10/01/1992 - "The results of this study show that CI-959 significantly reduces the myocardial infarct size without causing scar thinning, which might lead to ventricular aneurysm, and suggests the most likely mechanism for its beneficial action is the prevention of formation of toxic oxygen radicals." 10/01/1992 - "CI-959, a cell-activation inhibitor that prevents the formation of oxygen-derived free radicals by inflammatory cells, was studied to determine its effects on myocardial infarct size and subsequent scar formation in dogs. "
3.	Aneurysm (Aneurysms) 10/01/1992 - "The results of this study show that CI-959 significantly reduces the myocardial infarct size without causing scar thinning, which might lead to ventricular aneurysm, and suggests the most likely mechanism for its beneficial action is the prevention of formation of toxic oxygen radicals."
4.	Body Weight (Weight, Body) 04/12/1995 - "CI-959 generally did not suppress immunological responses in rats at doses lower than those which also altered body weight gain and reduced spleen and thymus weights. " 01/01/1989 - "Decreased body weight and histopathological lesions were observed in the thymus and spleen of rats administered 100 mg/kg CI-959. "
5.	Tooth Loss 10/01/2019 - "Among women, the analyses showed 1159 (95% CI: 959-1359) additional persons with tooth loss per 10 000 persons. "

Related Drugs and Biologics

1.	Reactive Oxygen Species (Oxygen Radicals)
2.	Oxygen (Dioxygen)
3.	Free Radicals
4.	Catecholamines
5.	Anti-Inflammatory Agents (Anti-Inflammatories)
6.	Actins (F Actin)
7.	benzothiophene

Related Therapies and Procedures

1.	Intravenous Administration
2.	Intravenous Infusions