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C6- (N1- methyl- 1,2,3- trazolylmethylene)penem
structure given in first source
Also Known As:
BRL 42715; BRL-42715; 4-Thia-1-azabicyclo(3.2.0)hept-2-ene-2-carboxylic acid, 6-((1-methyl-1H-1,2,3-triazol-4-yl)methylene)-7-oxo-, sodium salt, (R-(Z))-
Networked:
3
relevant articles (
1
outcomes,
2
trials/studies)
Relationship Network
Bio-Agent Context: Research Results
Organic Chemicals: 133
Amides: 2428
Lactams: 2198
C6-(N1-methyl-1,2,3-trazolylmethylene)penem: 3
Heterocyclic Compounds: 198
1-Ring Heterocyclic Compounds
Lactams: 2198
C6-(N1-methyl-1,2,3-trazolylmethylene)penem: 3
Related Diseases
1.
Infections
07/01/1992 - "
However, when the antibiotics were coadministered with BRL 42715, bacterial numbers were reduced significantly and all animals survived at least 16 h after infection.
"
07/01/1992 - "
Simulation of human serum pharmacokinetics of cefazolin, piperacillin, and BRL 42715 in rats and efficacy against experimental intraperitoneal infections.
"
07/01/1992 - "
Studies were performed to determine the effects of BRL 42715, a potent beta-lactamase inhibitor, on the activity of cefazolin and piperacillin against experimental intraperitoneal infections caused by either Escherichia coli or Serratia marcescens in rats.
"
2.
Tuberculosis (Tuberculoses)
03/01/1992 - "
These studies support the potential value of penicillin/clavulanic acid and penicillin/BRL 42715 combinations in the treatment of tuberculosis.
"
3.
Bacillary Dysentery (Shigellosis)
01/01/1993 - "
The effect of a powerful inhibitor, BRL 42715, on beta-lactamase from Shigella flexneri UCSF-129, to overcome the problem of shigellosis and its resistance to ampicillin, was studied.
"
Related Drugs and Biologics
1.
Piperacillin
2.
Cefazolin (Ancef)
3.
beta-Lactamase Inhibitors
4.
Clavulanic Acid (Potassium Clavulanate)
5.
Penicillins (Penicillin)
6.
beta-Lactamases (beta-Lactamase)
7.
Anti-Bacterial Agents (Antibiotics)
8.
Ampicillin (Omnipen)