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proinsulin endopeptidase II

involved in proteolytic conversion of proinsulin into insulin; cleaves preferentially on the C-terminal side of Lys 64.Arg 65 of proinsulin (C-peptide/A-chain junction); pH optinum 5.5; not inhibited by inhibitors of aspartic proteinases
Also Known As:
Ca-dependent acidic endoprotease type II; calcium dependent acidic endopeptidase II; insulin secretory granule type II endopeptidase
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