calphostin complex

structure given in first source; isolated from Cladosporium cladosporioides; complex of five closely related components, calphostin A,B,C,D & I; see also records for specifics

Also Known As:

Networked: 5 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Horton, Jureta W: 2 articles (10/2007 - 02/2007)
2.	Maass, David L: 2 articles (10/2007 - 02/2007)
3.	Tan, Jing: 2 articles (10/2007 - 02/2007)
4.	White, D Jean: 2 articles (10/2007 - 02/2007)
5.	Alston, Eric N: 1 article (03/2012)
6.	Carter, Emma: 1 article (03/2012)
7.	Cranley, James: 1 article (03/2012)
8.	Girard, Beatrice M: 1 article (03/2012)
9.	Habecker, Beth A: 1 article (03/2012)
10.	Herring, Neil: 1 article (03/2012)

Related Diseases

1.	Burns 10/01/2007 - "Administration of calphostin to inhibit PKC activity prevented both the burn-related decrease in myocardial Na-K-ATPase and the rise in intracellular Na(+) and improved postburn myocardial contractile performance. " 10/01/2007 - "Additional groups of sham burn-injured and burn-injured rats were given calphostin, an inhibitor of PKC, and Na-K-ATPase activity, cell Na(+), and myocardial function were measured. " 02/01/2007 - "Pretreating cardiomyocytes with either calphostin or PKCepsilon inhibitory peptide, a potent inhibitor of PKCepsilon, prevented burn serum-related redistribution of the PKCepsilon isoform and prevented burn serum-related cardiomyocyte secretion of TNF-alpha, IL-1beta, IL-6, and IL-10. "
2.	Neoplasms (Cancer) 03/01/2007 - "Apoptosis signalling mechanisms in human cancer cells induced by Calphostin-PDT."
3.	Bradycardia 03/01/2012 - "The protein kinase C inhibitor calphostin (100 nM, n=6) abolished the effect of galanin on vagal bradycardia whilst the protein kinase A inhibitor H89 (500 nM, n=6) had no effect. "
4.	Adenoma (Adenomas) 11/26/1999 - "Analysis of DNA synthesis in inhibitor-treated cultures indicated that H7 caused strong inhibition in all cell lines, while the more specific inhibitor calphostin was effective only in VACO235 adenoma cells. "

Related Drugs and Biologics

1.	Adenosine Triphosphatases (ATPase)
2.	Protein Isoforms (Isoforms)
3.	Galanin
4.	Interleukin-10 (Interleukin 10)
5.	Interleukin-6 (Interleukin 6)
6.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
7.	Protein Kinase C
8.	DNA (Deoxyribonucleic Acid)
9.	peptide A
10.	N- (2- (4- bromocinnamylamino)ethyl)- 5- isoquinolinesulfonamide (h89)