L 670596

thromboxane and prostaglondin endoperoxide receptor antagoist; structure given in first source

Also Known As:

L-670,596; 1H-Carbazole-1-acetic acid, 6,8-difluoro-2,3,4,9-tetrahydro-9-((4-(methylsulfonyl)phenyl)methyl)-, (-)-

Networked: 2 relevant articles (0 outcomes, 1 trials/studies)

1.	Respiratory Hypersensitivity 09/01/1990 - "In this study, two thromboxane receptor antagonists, L-655,240 and L-670,596, were used in doses that inhibit the response to an inhaled thromboxane mimetic, U-46619, to determine further the role of thromboxane in ozone-induced airway hyperresponsiveness. "
2.	Coronary Thrombosis 04/01/1994 - "In the dog model of electrically induced coronary thrombosis, occlusion time in control animals (n = 14) averaged 72 +/- 29 min. L 670596 alone dose-dependently antagonized platelet PGH2/TXA2 receptors and prolonged occlusion time. "

1.	15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid
2.	Thromboxane Receptors (Thromboxane Receptor)
3.	Thromboxanes
4.	Ozone
5.	Prostaglandin H2 (PGH(2))