human ITGB3 protein (HPA-1a)

RefSeq NM_000212;

Also Known As:

HPA-1a; ITGB3 protein, human; 1a alloantigen, human; CD61 antigen, human; P1A protein, human; PL(A1) antigen, human; PLA1 alloantigen, human; PLA1 antigen, human; Pl(A) alloantigen, human; Zw(a) antigen, human; human platelet antigen 1a; integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61), human; platelet membrane glycoprotein IIIa, human; platelet specific antigen PL(A), human; platelet specific antigen PL(A1), human

Networked: 106 relevant articles (2 outcomes, 7 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Membrane Proteins: 10078
    - Cell Surface Receptors: 2125
      - Immunologic Receptors: 9
        Integrins: 14304
        Integrin beta Chains: 15
        Integrin beta3: 704
        human ITGB3 protein: 106

Experts

1.	Santoso, Sentot: 8 articles (11/2019 - 12/2005)
2.	Kjeldsen-Kragh, Jens: 6 articles (10/2020 - 01/2012)
3.	Bakchoul, Tamam: 6 articles (01/2020 - 08/2007)
4.	Bein, Gregor: 6 articles (11/2019 - 08/2007)
5.	Ouwehand, Willem H: 6 articles (07/2013 - 04/2004)
6.	Husebekk, Anne: 5 articles (01/2021 - 01/2012)
7.	Williamson, Lorna M: 5 articles (07/2013 - 04/2004)
8.	Brojer, Ewa: 4 articles (01/2021 - 01/2015)
9.	Dębska, Marzena: 4 articles (01/2021 - 01/2015)
10.	Guz, Katarzyna: 4 articles (01/2021 - 01/2015)

Related Diseases

1.	Neonatal Alloimmune Thrombocytopenia 05/01/2003 - "The purpose of the study was to determine the prevalence of the HPA-1a negative platelet phenotype in a cohort of pregnant women in Ireland, the rate of alloimmunisation to HPA-1a in HPA-1 mismatched pregnancies and the associated incidence of neonatal alloimmune thrombocytopenia. " 02/01/2020 - "Non-invasive fetal HPA-1a typing is a valuable tool to identify the pregnancies at risk of fetal and neonatal alloimmune thrombocytopenia (FNAIT). " 02/01/2020 - "Strategies to develop a prophylaxis for the prevention of HPA-1a immunization and fetal and neonatal alloimmune thrombocytopenia." 01/01/2019 - "Maternal HPA-1a antibody level and its role in predicting the severity of Fetal/Neonatal Alloimmune Thrombocytopenia: a systematic review." 07/01/2012 - "Would it be possible to prevent HPA-1a alloimmunization to reduce the incidence of fetal and neonatal alloimmune thrombocytopenia?"
2.	Transfusion Reaction 07/01/2004 - "Efficacy of HPA-1a (PlA1)-negative platelets in a patient with post-transfusion purpura." 10/01/1991 - "However, in vitro studies demonstrated that the patient's platelets were negative for HPA-1a and that anti-HPA-1a was present in the serum, both of which findings were consistent with the diagnosis of posttransfusion purpura. " 08/01/2007 - "HPA-1a serum samples derived from mothers with NAIT (n = 36) and from posttransfusion purpura patients (n = 2) as well as HPA-1b (n = 4), HPA-5b (n = 2), HPA-3a (n = 4), and HLA Class I (n = 2) alloantiserum samples from multitransfused patients were investigated in GASA and MAIPA assays. " 01/01/1996 - "Blood components--transfusion support in post-transfusion purpura due to HPA-1a Immunization." 08/01/1995 - "Cases of alloimmunization to HPA-1a and HPA-1b resulting in refractoriness to transfused platelets and the subsequent development of a posttransfusion purpura-like syndrome are reported. "
3.	Thrombocytopenia (Thrombopenia) 11/16/1999 - "Immunological study of the platelets from the patients with aloimmune thrombocytopenia showed the absence of HPA-1a in their mothers. " 06/01/1995 - "This study describes a pilot prospective screening programme for the antenatal detection of fetomaternal alloimmune thrombocytopenia (FMAIT) due to HPA-1a incompatibility. " 01/01/2008 - "Specificity and sensitivity for HPA-1a detection were assessed using sera from 140 cases of fetomaternal alloimmune thrombocytopenia (FMAIT). " 07/01/2007 - "HPA-1a antibody potency and bioactivity do not predict severity of fetomaternal alloimmune thrombocytopenia." 05/01/2006 - "These findings provide evidence for a heterogeneous humoral response against HPA-1a that may have potential clinical implications for alloimmune thrombocytopenia disorders."
4.	Birth Weight (Birth Weights) 12/01/2023 - "The objective of this study was to assess how maternal HPA-1a alloimmunization, sex of the neonate and birth weight relates in a large prospective cohort. " 12/01/2023 - "Lower birth weight in boys from HPA-1a alloimmunized pregnancies - New insights from a large prospective screening study in Poland." 12/01/2023 - "Various multivariate models were used to assess if and how maternal HPA-1a alloimmunization status was associated with birth weight and risk of having a small for gestational age (SGA) neonate, and if and how sex of the neonate mattered. " 11/01/2022 - "It is well known that HPA-1a antibodies lead to fetal and neonatal alloimmune thrombocytopenia (FNAIT), and an association with reduced birthweight in boys has been reported. "
5.	Hemorrhage 01/01/2021 - "These mice developed a strong alloimmune response specific for HPA-1a, and when bred with HPA-1a+ males, gave birth to severely thrombocytopenic pups that exhibited an accompanying bleeding phenotype. " 01/01/2020 - "Samples of HPA-1a immunised pregnancies with and without signs of bleeding will be compared with identify parameters for identification of pregnancies at high risk for bleeding complications. " 12/01/2005 - "Interestingly, all four neonates with inhibitory HPA-1a alloabs (9% of all sera) suffered severe bleeding. " 01/01/2009 - "Our data suggest that HPA-1a alloantibodies have a direct effect on endothelial cell spreading and monolayer integrity, which could contribute to the increased bleeding tendency in children with neonatal alloimmune thrombocytopenia." 01/01/2021 - "Administering either polyclonal intravenous immunoglobulin G or a human monoclonal blocking antibody specific for the HPA-1a epitope into pregnant female mice resulted in significant elevation of the neonatal platelet count, normalized hemostasis, and prevented bleeding. "

Related Drugs and Biologics

1.	DNA (Deoxyribonucleic Acid)
2.	Antibodies
3.	Antigens
4.	Isoantibodies
5.	Human Platelet Antigens
6.	HLA-DRB3 Chains (HLA DRB3)
7.	Immunoglobulin G (IgG)
8.	Glycoproteins (Glycoprotein)
9.	Integrins
10.	Immunoglobulins (Immunoglobulin)

Related Therapies and Procedures

1.	Therapeutics
2.	Donor Selection
3.	Stem Cell Transplantation
4.	Platelet Transfusion (Blood Platelet Transfusions)
5.	Liver Transplantation