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dynemicin A

structure given in first source; isolated from Micromonospora

Networked: 3 relevant articles (1 outcomes, 0 trials/studies)

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Bio-Agent Context: Research Results

Experts

1.	Beane, Angus: 1 article (01/2017)
2.	Miller, Bill R: 1 article (01/2017)
3.	Parish, Carol A: 1 article (01/2017)
4.	Cremer, Dieter: 1 article (03/2008)
5.	Kraka, Elfi: 1 article (03/2008)
6.	Tuttle, Tell: 1 article (03/2008)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2017 - "This property of dynemicin A makes it a promising anti-tumor agent. " 12/01/1991 - "Dynemicin A showed extremely potent in vitro cytotoxicity against a variety of murine and human tumor cells. " 03/06/2008 - "However, if protonated in the acidic environment of the tumor cell, they possess increased biological activity, as is reflected by a lowering of the activation enthalpy for the Bergman cyclization from 16.7 (dynemicin A) to 11-12 kcal/mol (DADs), kinetic stability of the singlet biradicals formed in the cyclization reaction, increased H abstraction ability of the singlet biradicals, and improved docking properties in the minor groove of the duplex 10-mer B-DNA sequence d(CTACTACTGG).d(CCAGTAGTAG) throughout the triggering and Bergman reactions. " 12/01/1991 - "In the experimental animal tumor models implanted ip with P388, L1210 leukemias and B16 melanoma cells, dynemicin A administered ip significantly prolonged life-span of tumor-bearing mice with the wide range of activity. "
2.	Experimental Melanoma 12/01/1991 - "In the macromolecule biosynthesis of B16 melanoma cells, dynemicin A inhibited DNA synthesis specifically. " 12/01/1991 - "In the experimental animal tumor models implanted ip with P388, L1210 leukemias and B16 melanoma cells, dynemicin A administered ip significantly prolonged life-span of tumor-bearing mice with the wide range of activity. "
3.	Leukemia 12/01/1991 - "In the experimental animal tumor models implanted ip with P388, L1210 leukemias and B16 melanoma cells, dynemicin A administered ip significantly prolonged life-span of tumor-bearing mice with the wide range of activity. "

Related Drugs and Biologics

1.	B-Form DNA (B-DNA)
2.	DNA (Deoxyribonucleic Acid)