15-phenyl-beta-methylpentadecanoic acid

05/29/2018 - "However, MPPa and NMPi were not effective against large-size tumors. "
05/01/2011 - "Moreover, after MPPa-mediated SDT cancer cells showed swollen mitochondria under TEM and a significant collapse of mitochondrial membrane potential. "
05/29/2018 - "MPPa and NMPi showed high anticancer efficacy against small-size tumors, indicating that early treatment with PDT is effective. "
01/01/2023 - "Together, these results demonstrate that the developed MPPa-loaded SLNs are promising candidates for cancer treatment using PDT."
01/01/2023 - "The pharmacological effect of MPPa was evaluated using the 1,3-diphenylisobenzofuran (DPBF) assay and anti-cancer effect against HeLa and A549 cell lines. "

11/01/2017 - "The present study was performed to establish and characterize new human osteosarcoma cell lines resistant to pyropheophorbide-α methyl ester‑mediated photodynamic therapy (MPPa-PDT). "
10/09/2021 - "RhoA enhances osteosarcoma resistance to MPPa-PDT via the Hippo/YAP signaling pathway."
11/01/2017 - "MPPa-PDT-resistant cells are isolated from the human osteosarcoma MG63 and HOS cell lines and two resistant populations were finally acquired, including MG63/PDT and HOS/PDT. "
06/08/2016 - "Human osteosarcoma MG63 cells in logarithmic growth phase were divided into 4 groups: blank control group (control group), the MPPa treatment group (MPPa group), the light irradiation group (LED group), and MPPa-PDT treatment group (MPPa-PDT group). "
09/01/2022 - "These data indicate that ferroptosis and YAP knockdown can enhance osteosarcoma cell sensitivity to MPPa-PDT therapy."

11/29/2019 - "Thus, MPPa-PDT may be a promising treatment to inhibit metastasis."
11/29/2019 - "Taken together, these results demonstrate that MPPa-PDT inhibits the metastasis of MCF-7 cells both in vitro and in vivo and may be involved in the Akt/NF-κB-dependent MMP-9 signaling pathway. "
11/29/2019 - "MPPa-PDT downregulated the expression of MMP2 and MMP9, which are responsible for the initiation of metastasis. "
11/29/2019 - "Moreover, MPPa-PDT inhibited tumor metastasis and destroyed F-actin in vivo. "
11/29/2019 - "In the present study, pyropheophorbide-α methyl ester-mediated photodynamic therapy (MPPa-PDT) was used to inhibit metastasis in MCF-7 breast cancer cells. "

05/01/2011 - "The present study aims to investigate the mitochondrial damage of liver cancer cells induced by MPPa-mediated sonodynamic action. "
07/01/2010 - "Our findings showed that MPPa-mediated sonodynamic action significantly enhanced death of H22 cells and the ROS level, suggesting that MPPa is a novel sonosensitizer and the sonodynamic action of MPPa might be a potential therapeutic modality in the management of liver cancer."
07/01/2010 - "H22 cells were chosen as model cells to investigate the sonodynamic action of MPPa on liver cancer. "
07/01/2010 - "This study aimed to investigate the sonodynamic action of pyropheophorbide-a methyl ester (MPPa) in liver cancer cells to explore a novel therapeutic modality. "
05/01/2011 - "Sonodynamic therapy with pyropheophorbide-a methyl ester (MPPa) presents a promising aspect in treating liver cancer. "

01/01/2017 - "The present study investigated the effect of MPPa-mediated photodynamic treatment on lung cancer A549 cells as well as the underlying mechanisms. "
08/01/2016 - " expression of Bax was increased,and that of Bcl-2was decreased.MPPa-photodynamic therapy can significantly suppress cell viability,and induce apoptosis in human cisplatin-resistance lung cancer cells."
08/01/2016 - " provide experimental basis for its application in cisplatin-resistance lung cancer,we will discuss the biological effects of MPPa-photodynamic therapy in human cisplatin-resistance lung cancer cells in this article.Human"
08/01/2016 - "[Induction of Apoptosis of Human Cisplatin-resistance Lung Cancer Cells with MPPa-photodynamic Therapy]."
08/01/2016 - " cisplatin-resistance lung cancer cells A549/DDP were co-cultured with MPPa(0,1,2,4,8,16μmol/L)and exposed to light(0,0.6,1.2,2.4,3.6,4.8J/cm2),and cell viability was determined with CCK-8assay.Flow cytometry was used to detect apoptosis,DCFH-DA staining was employed to observe reactive oxygen species(ROS),and Western blot was used to detect the expressions of B-cell lymphoma-2(Bcl-2)protein and Bcl-2associated X protein(Bax).The proliferation of A549/DDP cells was suppressed by PDT.The"