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aprikalim

Also Known As:
N-methyl-2-(3-pyridyl)tetrahydrothiopyran-2-carbothioamide-1-oxide; RP 49356; RP 52891; RP-49356; RP-52891
Networked: 33 relevant articles (3 outcomes, 2 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Rokkas, Chris K: 1 article (01/2013)
2. Lozos, Vasileios A: 1 article (01/2013)
3. Rizos, Ioannis K: 1 article (01/2013)
4. Agrogiannis, Georgios: 1 article (01/2013)
5. Toumpoulis, Ioannis K: 1 article (01/2013)
6. Patsouris, Efstratios S: 1 article (01/2013)
7. Anagnostopoulos, Constantine E: 1 article (01/2013)
8. Giamarellos-Bourboulis, Evangelos J: 1 article (01/2013)
9. Chamogeorgakis, Themistocles P: 1 article (01/2013)
10. Tang, Daniel G: 1 article (06/2004)

Related Diseases

1. Myocardial Infarction
07/01/1993 - "Similarly, aprikalim at a non-hypotensive dose reduced myocardial infarct size in dogs subjected to 90 min of ischaemia and 5 h of reperfusion, and the protective effects of aprikalim were antagonized completely by glibenclamide. "
12/01/1991 - "However, myocardial infarct size, expressed as a percentage of the area at risk, was significantly (P less than .05) reduced (38%) by RP 52891 and significantly increased (38%) by glibenclamide (vehicle, 39 +/- 4%; RP 52891, 24 +/- 2%; and glibenclamide, 54 +/- 5%).(ABSTRACT TRUNCATED AT 250 WORDS)"
08/01/1994 - "Similarly, in a model of irreversible ischaemia/reperfusion injury (90 min of coronary artery occlusion followed by 5 h of reperfusion), intravenous infusion of bimakalim at a dose which reduced aortic blood pressure approximately 15-20 mmHg or infusion of aprikalim at a non-hypotensive dose throughout the entire experiment produced a significant reduction in myocardial infarct size. "
02/22/2002 - "Early intervention by intravenous infusion of nicorandil (100 microg/kg bolus+10 microg/kg/min) or aprikalim (10 microg/kg bolus+0.1 microg/kg/min) just before and during ischemia increased survival rate (86% and 75% vs. 55% in the control group), significantly decreased the incidence and severity of life-threatening arrhythmias and myocardial infarct size. "
12/01/1991 - "The objective of the present study was to determine the effect of a novel K+ channel opener, Aprikalim (RP 52891; [trans-(-)-N-methyl-2-(3-pyridyl)-2-tetrahydrothio-pyran carbothiamide-1-oxide]), on myocardial infarct size in barbital-anesthetized dogs subjected to 90 min of left circumflex coronary artery occlusion followed by 5 hr of reperfusion. "
2. Reperfusion Injury
3. Spinal Cord Ischemia
4. Stroke (Strokes)
5. Ischemia

Related Drugs and Biologics

1. Glyburide (Glibenclamide)
2. bimakalim
3. salicylhydroxamic acid (SHAM)
4. aprikalim
5. Barbital (Barbitone)
6. Adenosine Triphosphate (ATP)
7. Potassium Channels (Potassium Channel)
8. Nicorandil (SG 75)
9. Potassium
10. Nitroprusside (Sodium Nitroprusside)

Related Therapies and Procedures

1. Intravenous Infusions
2. Induced Heart Arrest (Cardioplegia)