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L- 3- (3- hydroxy- 4- pivaloyloxyphenyl)alanine

structure given in first source

Also Known As:

NB 355; NB-355; L-Tyrosine, 3-hydroxy-, 4-(2,2-dimethylpropanoate)

Networked: 1 relevant articles (1 outcomes, 0 trials/studies)

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Bio-Agent Context: Research Results

Related Diseases

1.	Dyskinesias (Dyskinesia) 10/01/1989 - "Our findings suggest that NB-355 may be a useful therapeutic agent for increasing the duration of action of L-DOPA and reducing the severity of peak-dose dyskinesia." 10/01/1989 - "NB-355: a novel prodrug for L-DOPA with reduced risk for peak-dose dyskinesias in MPTP-treated squirrel monkeys." 10/01/1989 - "We have examined the ability of a novel catechol monoester of L-DOPA, NB-355 [L-3-(3-hydroxy-4-pivaloxyloyphenyl)alanine], to stimulate locomotor activity and induce dyskinesias in MPTP-treated primates. "
2.	Drug-Induced Dyskinesia (Dyskinesia, Drug Induced) 10/01/1989 - "At these doses, drug-induced dyskinesias were less severe following treatment with NB-355 than with L-DOPA. "

Related Drugs and Biologics

1.	Levodopa (L Dopa)
2.	1- Methyl- 4- phenyl- 1,2,3,6- tetrahydropyridine (MPTP)
3.	Prodrugs
4.	Alanine (L-Alanine)
5.	catechol (pyrocatechol)