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Org 7797
structure given in first source
Also Known As:
Org-7797; Estra-1,3,5(10)-triene-3,16-diol, 17-(methylamino)-, (16alpha,17beta)-, (Z)-2-butenedioate (1:1) (salt)
Networked:
7
relevant articles (
2
outcomes,
0
trials/studies)
Relationship Network
Bio-Agent Context: Research Results
Polycyclic Compounds: 6
Fused-Ring Compounds
Steroids: 70059
Estranes
Estrenes
Org 7797: 7
Related Diseases
1.
Ventricular Fibrillation
12/01/1992 - "
Following anaesthesia, Org 7797 reduced the severity of arrhythmias induced by coronary artery occlusion and prevented the accompanying decrease in the ventricular fibrillation threshold (VFT) at 1 h after completion of dosing.
"
12/01/1991 - "
2. Org 7797 (0.5 mg kg-1) significantly reduced the expected incidence of early ischaemia-induced ventricular fibrillation (VF) in rats and greyhound dogs and at doses of 0.5-1.0 mg kg-1 antagonized reperfusion-induced arrhythmias.
"
04/01/1990 - "
Org 7797 is effective against ventricular fibrillation (VF) induced during ischemia.
"
03/01/1992 - "
One hour after acute coronary artery occlusion, the only significant hemodynamic effect of an intravenous (i.v.) dose of Org 7797 (0.5 mg/kg) known to prevent ischemia-induced ventricular fibrillation (VF) in dogs was a decrease in heart rate (HR) (of 3%) while cardiac output (CO), stroke volume (SV), and left ventricular (LV) dP/dtP-1 were unchanged.
"
2.
Ischemia
04/01/1990 - "
Org 7797 is effective against ventricular fibrillation (VF) induced during ischemia.
"
03/01/1992 - "
One hour after acute coronary artery occlusion, the only significant hemodynamic effect of an intravenous (i.v.) dose of Org 7797 (0.5 mg/kg) known to prevent ischemia-induced ventricular fibrillation (VF) in dogs was a decrease in heart rate (HR) (of 3%) while cardiac output (CO), stroke volume (SV), and left ventricular (LV) dP/dtP-1 were unchanged.
"
3.
Myocardial Infarction
09/01/1993 - "
This preferential action on the AV node may contribute to the control of ventricular rate during atrial fibrillation in the absence of infra-nodal conduction disturbances.7. These results contrast with those previously obtained in infarcted dogs and might further suggest that myocardial infarction enhances the Class I action of Org 7797.
"
03/01/1992 - "
The hemodynamic effects of a new Ic antiarrhythmic agent (Org 7797) were compared with those of flecainide and propafenone in anesthetized pigs with developing myocardial infarcts.
"
03/01/1992 - "
Comparative hemodynamic effects of Org 7797, flecainide, and propafenone in anesthetized pigs with developing myocardial infarcts.
"
12/01/1991 - "
4. Org 7797 (0.5 and 2.0 mg kg-1), flecainide (1.0 and 2.0 mg kg-1) or propafenone (0.5 and 2.0 mg kg-1), did not significantly prevent induction of tachyarrhythmias (VT) in dogs with 5-6 day old myocardial infarcts although all 3 drugs appeared to prevent induced VF.
"
10/01/1991 - "
1. The electrophysiological effects of intravenously administered Org 7797 were compared with those of disopyramide (class Ia), mexiletine (Ib) and propafenone (Ic) in anaesthetized dogs with 5-6 day-old left ventricular myocardial infarcts.
"
4.
Atrial Fibrillation
01/01/1991 - "
Under control conditions, paroxysms of atrial fibrillation were induced by burst pacing (50 Hz; inducibility 100%) and persisted on the average for greater than 3 min. Org 7797 (1, 2, and 3 mg/kg/h) significantly reduced both inducibility and duration of atrial fibrillation to 25 and 10%, respectively.
"
01/01/1991 - "
Mode of action of a new class IC drug (ORG 7797) against atrial fibrillation in conscious dogs.
"
09/01/1993 - "
This preferential action on the AV node may contribute to the control of ventricular rate during atrial fibrillation in the absence of infra-nodal conduction disturbances.7. These results contrast with those previously obtained in infarcted dogs and might further suggest that myocardial infarction enhances the Class I action of Org 7797.
"
5.
Ventricular Tachycardia
04/01/1990 - "
In no instance when Org 7797 was present (2-10 microM) could VF be induced, although sustained and nonsustained ventricular tachycardias (VTs) could still be initiated in about two thirds of treated hearts.
"
Related Drugs and Biologics
1.
Propafenone (Rythmol)
2.
Flecainide (Tambocor)
3.
Mexiletine (Mexitil)
4.
Disopyramide (Norpace)