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RP 170
structure given in first source
Also Known As:
1,3-Propanediol, 2-((2-nitro-1H-imidazol-1-yl)methoxy)-; 1-(2-hydroxy-1-(hydroxymethyl)ethoxy)methyl-2-nitroimidazole; RP-170
Networked:
6
relevant articles (
1
outcomes,
0
trials/studies)
Relationship Network
Bio-Agent Context: Research Results
Organic Chemicals: 133
Nitro Compounds: 66
Nitroimidazoles: 565
RP 170: 6
Heterocyclic Compounds: 198
1-Ring Heterocyclic Compounds
Azoles: 2138
Imidazoles: 150
Nitroimidazoles: 565
RP 170: 6
Carbohydrates: 22023
Glycosides: 2119
Nucleosides: 6847
RP 170: 6
Nucleic Acids, Nucleotides, and Nucleosides: 1
Nucleosides: 6847
RP 170: 6
Experts
1.
Khlebnikov, Andrei
: 1 article (04/2002)
2.
Kwon, Byoung Se
: 1 article (04/2002)
3.
Schepetkin, Igor
: 1 article (04/2002)
Related Diseases
1.
Neoplasms (Cancer)
01/01/1995 - "
Therefore, RP-170 combined with exposure to heat may be an effective treatment for hypoxic cells in a solid tumor, as these cells are resistant to radiation and/or to many chemotherapeutic agents.
"
06/15/1994 - "
RP-170 showed neither signs of toxicity nor significant alterations in glucose metabolism in brain or tumor at doses up to 4 g/kg b.w.
"
06/15/1993 - "
The maximum tumor concentration/AUC for brain (Cmax,tumor/AUCbrain) ratios for RP-343 and RP-170 were 9.62 and 3.98.
"
09/01/1989 - "
The in vivo-in vitro excision analysis showed that RP-170 was also as effective as MISO and etanidazole to radiosensitize solid tumor cells in vivo.
"
01/01/1992 - "
An intravenous administration (i.v.) of 100 mg/kg of RP-170 or the same dose of etanidazole showed an equal sensitizer enhancement ratio (SER) of about 1.4 to solid EMT6 tumor under in vivo-in vitro assay and a virtually equal SER of 1.4-1.5 to solid SCC VII tumor under tumor growth delay assay.
"
2.
Neoplasm Metastasis (Metastasis)
04/01/2002 - "
A QSAR analysis of the anti-tumor, anti-metastasis and anti-colony formation (for metastatic colonies) activities of eighteen nitroazoles (including metronidazole and hypoxic radiosensitizers RP-170, KU-2285 and sanazole (drug AK-2123)) and their nitro and nitroso anion radical derivatives against melanoma B16 in mice has been performed.
"
3.
Experimental Melanoma
04/01/2002 - "
A QSAR analysis of the anti-tumor, anti-metastasis and anti-colony formation (for metastatic colonies) activities of eighteen nitroazoles (including metronidazole and hypoxic radiosensitizers RP-170, KU-2285 and sanazole (drug AK-2123)) and their nitro and nitroso anion radical derivatives against melanoma B16 in mice has been performed.
"
4.
Hypoxia (Hypoxemia)
01/01/1995 - "
The concomitant treatment of RP-170 and heat inhibited the clonogenic activity of the EMT6/KU cells under conditions of in vitro hypoxia in all experimental groups, with a significant difference (p < 0.05).
"
01/01/1995 - "
Hypoxia also reduced the surviving fraction of the cells treated either with RP-170 alone or with RP-170 plus heat.
"
5.
Hyperthermia
01/01/1995 - "
Hyperthermia enhances the cytotoxicity against hypoxic cells of RP-170, a new 2-nitroimidazole nucleoside hypoxic cell sensitizer.
"
Related Drugs and Biologics
1.
Etanidazole
2.
Nucleosides
3.
KU 2285
4.
azomycin
5.
Metronidazole (Metric)
6.
Glucose (Dextrose)
7.
Anions
8.
1- (1',3',4'- trihydroxy- 2'- butoxy)methyl- 2- nitroimidazole
9.
AK 2123
10.
1- (4'- hydroxy- 2'- butenoxy)methyl- 2- nitroimidazole (RK 28)
Related Therapies and Procedures
1.
Intravenous Administration
2.
Intravenous Injections
3.
Oral Administration