baohuoside I

structure given in first source; isolated from the herb Epimedium davidii

Also Known As:

3,5,7-trihydroxy-4'-methoxyl-8-prenylflavone-3-O-rhamnopyranoside; icarisid II; icariside II; 4H-1-Benzopyran-4-one, 3-((6-deoxy-alpha-L-mannopyranosyl)oxy)-5,7-dihydroxy-2-(4-methoxyphenyl)-8-(3-methyl-2-butenyl)-

Networked: 108 relevant articles (10 outcomes, 24 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrans: 130
    - Benzopyrans: 195
      - Chromones: 159
        Flavonoids: 9773
        baohuoside I: 108
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Benzopyrans: 195
      - Chromones: 159
        Flavonoids: 9773
        baohuoside I: 108

Experts

1.	Gong, Qihai: 9 articles (01/2020 - 01/2016)
2.	Wu, Jinfeng: 7 articles (01/2020 - 09/2012)
3.	Jia, Xiaobin: 7 articles (12/2019 - 07/2012)
4.	Deng, Yuanyuan: 7 articles (03/2019 - 01/2016)
5.	Gao, Jianmei: 6 articles (01/2020 - 01/2016)
6.	Sun, E: 6 articles (11/2016 - 01/2012)
7.	Shi, Jingshan: 5 articles (01/2020 - 01/2016)
8.	Xu, Jinhua: 5 articles (01/2020 - 09/2012)
9.	Song, Jie: 5 articles (11/2017 - 07/2012)
10.	Zhang, Zhenhai: 5 articles (11/2017 - 07/2012)

Related Diseases

1.	Inflammation (Inflammations) 01/01/2020 - "Histological analysis using H&E, PAS and Masson staining showed that administration of Icariside II attenuated OVA-induced airway inflammation and remodeling. " 09/01/2023 - "TMT-based quantitative proteomics revealed protective efficacy of Icariside II against airway inflammation and remodeling via inhibiting LAMP2, CTSD and CTSS expression in OVA-induced chronic asthma mice." 01/01/2020 - "The present study aimed to investigate the effects and mechanisms of Icariside II on airway inflammation and remodeling in asthma. " 01/01/2020 - "In both OVA-induced mouse model of asthma and TGF-β1-induced ASMCs, Icariside II decreased IκBα degradation, nuclear translocation of NF-κB p65 and STAT3 phophorylation, indicating an inactivation of NF-κB and STAT3 in the presence of Icariside II. Therefore, we demonstrate that Icariside II attenuates eosinophils-induced airway inflammation and remodeling in asthmatic mice and inhibits TGF-β1-induced cell proliferation and migration in ASMCs via suppressing NF-κB and STAT3 signalings." 01/01/2020 - "These results suggested that Icariside II inhibited eosinophil activation and thus decreased eosinophils-induced airway inflammation and remodeling in asthma. "
2.	Ovarian Neoplasms (Ovarian Cancer) 01/01/2022 - "These results may be beneficial for future studies on the use of Icariside II to treat ovarian cancer." 10/01/2023 - "Consequently, Baohuoside I might be evaluated as a new agent for enhancing the chemotherapeutic efficacy of drug treatment for ovarian cancer." 10/01/2023 - "Moreover, Baohuoside I could inhibit the chemoresistance to DDP in ovarian cancer in vivo. Baohuoside I sensitizes ovarian cancer cells to DDP by suppressing autophagy via downregulating the HIF-1α/ATG5 axis. " 10/01/2023 - "Additionally, evaluation of Baohuoside I's role in ovarian cancer was performed using a nude mouse xenograft model. Baohuoside I decreased the viability and proliferation and triggered the apoptosis of both A2780 and A2780/DDP cells in a concentration-dependent manner. " 01/01/2022 - "Icariside II significantly decreased the expression of IGF2R and the phosphorylation level of AKT and mTOR in ovarian cancer cells, which were partially reversed by miR-144-3p inhibitor. "
3.	Cognitive Dysfunction 03/01/2018 - "Icariside II ameliorates ibotenic acid-induced cognitive impairment and apoptotic response via modulation of MAPK pathway in rats." 01/01/2018 - "Icariside II Ameliorates Cognitive Impairments Induced by Chronic Cerebral Hypoperfusion by Inhibiting the Amyloidogenic Pathway: Involvement of BDNF/TrkB/CREB Signaling and Up-Regulation of PPARα and PPARγ in Rats." 05/01/2022 - "Icarisid II rescues cognitive dysfunction via activation of Wnt/β-catenin signaling pathway promoting hippocampal neurogenesis in APP/PS1 transgenic mice." 01/01/2017 - "Icariside II, a Broad-Spectrum Anti-cancer Agent, Reverses Beta-Amyloid-Induced Cognitive Impairment through Reducing Inflammation and Apoptosis in Rats."
4.	Diabetic Cardiomyopathies 01/01/2018 - "Results from the present study suggested that treatment with icariside II improved diabetic cardiomyopathy in streptozotocin‑induced diabetic rats by activating the Akt/NOS/NF‑κB pathway." 01/01/2018 - "Effects of icariside II ameliorates diabetic cardiomyopathy in streptozotocin-induced diabetic rats by activating Akt/NOS/NF-κB signaling." 01/01/2018 - "The aim of the present study was to evaluate the effects icariside II on diabetic cardiomyopathy in streptozotocin-induced diabetic rats. " 01/02/2023 - "Furthermore, preclinical evidence has shown that icariin and its in vivo bioactive form, icariside II, have preventive and therapeutic effects on several diabetic complications, including diabetic cardiomyopathy, diabetic vascular endothelial disorder, diabetic nephropathy, and diabetic erectile dysfunction. "
5.	Asthma (Bronchial Asthma) 09/01/2023 - "TMT-based quantitative proteomics revealed protective efficacy of Icariside II against airway inflammation and remodeling via inhibiting LAMP2, CTSD and CTSS expression in OVA-induced chronic asthma mice." 01/01/2020 - "The present study aimed to investigate the effects and mechanisms of Icariside II on airway inflammation and remodeling in asthma. " 01/01/2020 - "In both OVA-induced mouse model of asthma and TGF-β1-induced ASMCs, Icariside II decreased IκBα degradation, nuclear translocation of NF-κB p65 and STAT3 phophorylation, indicating an inactivation of NF-κB and STAT3 in the presence of Icariside II. Therefore, we demonstrate that Icariside II attenuates eosinophils-induced airway inflammation and remodeling in asthmatic mice and inhibits TGF-β1-induced cell proliferation and migration in ASMCs via suppressing NF-κB and STAT3 signalings." 01/01/2020 - "These results suggested that Icariside II inhibited eosinophil activation and thus decreased eosinophils-induced airway inflammation and remodeling in asthma. " 01/01/2020 - "Icariside II attenuates eosinophils-induced airway inflammation and remodeling via inactivation of NF-κB and STAT3 in an asthma mouse model."

Related Drugs and Biologics

1.	Streptozocin (Streptozotocin)
2.	Phosphodiesterase 5 Inhibitors
3.	Brain-Derived Neurotrophic Factor (BDNF)
4.	Ibotenic Acid
5.	Blood Glucose (Blood Sugar)
6.	epimedii flavone
7.	Therapeutic Uses
8.	Flavonoids
9.	Glycosides
10.	3-hydroxyflavone

Related Therapies and Procedures

1.	Chinese Traditional Medicine (Traditional Chinese Medicine)
2.	Therapeutics
3.	Prostatectomy (Retropubic Prostatectomy)
4.	Aftercare (After-Treatment)