|1.||Agrawal, Anurag: 1 article (12/2012)|
|2.||Ghosh, Balaram: 1 article (12/2012)|
|3.||Khanna, Kritika: 1 article (12/2012)|
|4.||Aich, Jyotirmoi: 1 article (12/2012)|
|5.||Mabalirajan, Ulaganathan: 1 article (12/2012)|
|6.||Ahmad, Tanveer: 1 article (12/2012)|
|7.||Rehman, Rakshinda: 1 article (12/2012)|
|8.||Itoh, Toshiki: 1 article (04/2006)|
|9.||Furutani, Masahiro: 1 article (04/2006)|
|10.||Takenawa, Tadaomi: 1 article (04/2006)|
11/01/1999 - "The tumor suppressor PTEN negatively controls the phosphoinositide 3-kinase pathway for cell survival by dephosphorylating the phospholipid substrates phosphatidylinositol 3,4-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate. "
01/25/1990 - "Epidermal growth factor increases the labeling of phosphatidylinositol 3,4-bisphosphate in MA-10 Leydig tumor cells."
07/01/2000 - "The tumor suppressor function of the PTEN protein (PTEN) has been linked to its ability to dephosphorylate the lipid second-messenger phosphatidylinositol 3,4, 5-trisphosphate and phosphatidylinositol 3,4-bisphosphate and, by doing so, to antagonize the phosphoinositide 3-kinase pathway. "
04/01/2006 - "This method was applied to follow the generation of minor phosphoinositides, such as PtdIns(3,4,5)P3 and PtdIns(3,4)P2 in response to insulin and to compare PtdIns(4,5)P2 and PtdIns(3,4,5)P3 levels in several cancer cell lines. "
|2.||Thrombasthenia (Glanzmann Thrombasthenia)
06/02/1995 - "The synthesis of PtdIns(3,4)P2 induced by concanavalin A was also independent of the membrane glycoprotein IIb-IIIa, as normal accumulation of this lipid was observed in platelets from two patients affected by Glanzmann thrombasthenia. "
12/15/1991 - "In addition, pathological platelets from three patients suffering thrombasthenia, which lack alpha IIb-beta 3 integrin and fail to aggregate in response to thrombin, displayed hardly detectable increases in the 32P labeling of PtdIns(3,4)P2. "
|3.||Oculocerebrorenal Syndrome (Lowe Syndrome)
|4.||Glioblastoma (Glioblastoma Multiforme)
09/01/2000 - "We have examined the relative roles of the two major phospholipid products of PI3K activity, phosphatidylinositol 3,4-biphosphate [PtdIns(3,4)P2] and phosphatidylinositol 3,4,5-triphosphate [PtdIns(3,4,5)P3], in the regulation of PKB activity in glioblastoma cells containing high levels of both of these lipids due to defective PTEN expression. "
|5.||Acute Erythroblastic Leukemia (Erythroleukemia)
|7.||PTEN Phosphohydrolase (PTEN Phosphatase)
|8.||Platelet Membrane Glycoprotein IIb
|9.||Integrin beta3 (GPIIIa)
|10.||Phosphatidylinositol 4,5-Diphosphate (Phosphatidylinositol 4,5 Diphosphate)