membrane-bound adrenal trypsin-like enzyme (MATLE)

putative processing enzyme for proenkephalin with activity directed twoard basic residues; cleaves between & following the paired basic residues at positions 23 & 24 of Peptide B(thus generating (Met-enkephalin)-Arg-Phe & Arg-(Met-enkephalin)-Arg-Phe)
Also Known As:
MATLE; adrenal trypsin-like enzyme; proenkephalin cleaving enzyme
Networked: 6 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results


1. Malthankar-Phatak, Gauri H: 1 article (08/2006)
2. Kim, Jung H: 1 article (08/2006)
3. Spencer, Susan S: 1 article (08/2006)
4. Lai, James C K: 1 article (08/2006)
5. de Lanerolle, Nihal: 1 article (08/2006)
6. Behar, Kevin L: 1 article (08/2006)
7. Eid, Tore: 1 article (08/2006)
8. Spencer, Dennis D: 1 article (08/2006)

Related Diseases

1. Temporal Lobe Epilepsy
01/01/1999 - "Two groups of patients with medial temporal lobe epilepsy were used, those with medial temporal lobe sclerosis (MTLE), and those with extrahippocampal masses (MaTLE) where the cell loss and synaptic reorganization that characterize MTLE are not seen. "
10/01/1997 - "In hippocampi that were not the seizure focus (mass associated temporal lobe epilepsy, MaTLE; and paradoxical temporal lobe epilepsy, PTLE) DYN-like immunoreactivity was localized in the dentate granule cells and their mossy fiber terminals within the hilus and area CA3. "
01/01/1997 - "Hippocampal dentate granule cells in temporal lobe epilepsy (TLE) patients with mesial sclerosis (MTLE) are reported to be hyperexcitable compared to those in patients with a mass lesion outside the hippocampus (MaTLE) (Williamson, Clin Neurosci 1994;2: 47-52). "
10/01/1997 - "We directly assessed this hypothesis using quantitative in vitro receptor autoradiography to determine the densities of glutamate-, NMDA-, quisqualate/alpha-amino-3-hydroxy-5-methyl-isoxazoleproprionic acid (AMPA)- and kainic acid-preferring binding sites in surgically removed hippocampi from patients with mesial temporal lobe epilepsy (sclerosis; MTLE) and patients with mass-associated temporal lobe epilepsy (no sclerosis; MaTLE), compared with autopsy material. "
08/01/2006 - "Activities of four key enzymes involved in energy metabolism and glutamate cycling in the brain [aspartate aminotransferase (AAT), citrate synthase (CS), glutamate dehydrogenase (GDH), and lactate dehydrogenase (LDH)] were measured in anterolateral temporal neocortical and hippocampal tissues obtained from three different groups of medically intractable epilepsy patients having either mesial, paradoxical, or mass lesion-associated temporal lobe epilepsy (MTLE, PTLE, MaTLE), respectively. "
2. Sclerosis
3. Seizures (Seizure)
4. Epilepsy (Aura)

Related Drugs and Biologics

1. Glutamic Acid (Glutamate)
2. alpha- Amino- 3- hydroxy- 5- methyl- 4- isoxazolepropionic Acid (AMPA)
3. Quisqualic Acid
4. N-Methylaspartate (NMDA)
5. Tetrodotoxin (Tetradotoxin)
6. L-Lactate Dehydrogenase (Lactate Dehydrogenase)
7. Kainic Acid (Kainate)
8. Glutamate Dehydrogenase
9. Enzymes
10. Citrate (si)-Synthase (Synthase, Citrate)