|1.||Hawkins, Cynthia: 11 articles (11/2015 - 03/2010)|
|2.||Nazarian, Javad: 11 articles (08/2015 - 05/2012)|
|3.||Broniscer, Alberto: 11 articles (06/2015 - 12/2010)|
|4.||Bouffet, Eric: 11 articles (11/2014 - 02/2008)|
|5.||Warren, Katherine E: 10 articles (08/2015 - 10/2008)|
|6.||Grill, Jacques: 8 articles (12/2015 - 09/2011)|
|7.||Gajjar, Amar: 8 articles (06/2015 - 10/2011)|
|8.||van Vuurden, Dannis G: 8 articles (06/2015 - 01/2013)|
|9.||Bartels, Ute: 8 articles (11/2014 - 03/2010)|
|10.||Buczkowicz, Pawel: 7 articles (11/2015 - 03/2010)|
04/01/2012 - "Diffuse intrinsic pontine gliomas (DIPG) can not be cured with current treatment modalities. "
05/01/2014 - "The purpose of this study is to evaluate quantitative changes in diffusion tensor imaging (DTI) tractography and fractional anisotropy (FA) of the pons along with clinical correlation, in patients who receive re-irradiation for progressive diffuse intrinsic pontine glioma (DIPG). "
01/01/2013 - "To study the impact of multiparametric MRI and (18)F-FDG-PET on the outcome of children with diffuse intrinsic pontine gliomas (DIPG). "
11/01/2012 - "Pediatric diffuse intrinsic pontine glioma (DIPG) has a dismal prognosis that has not seen a change in outcome despite multiple clinical trials. "
07/01/2012 - "Despite numerous clinical trials over the past 2 decades, the overall survival for children diagnosed with diffuse intrinsic pontine glioma (DIPG) remains 9-10 months. "
07/01/2015 - "Recently, a surge in molecular studies of DIPG has occurred, in large part due to the increased availability of tumor tissue through donation of post-mortem specimens. "
07/01/2013 - "Imaging data were assessed at baseline, during, and after RT, and every other month thereafter until tumor progression for 35 patients (ages 2-16 years) with newly diagnosed DIPG enrolled in the phase I clinical study, NCT00472017. "
07/01/2013 - "This study investigated tumor perfusion and 3D segmented tumor volume as predictive markers for outcome in children with newly diagnosed DIPG. "
05/20/2015 - "NG2 expression is altered (symmetric segregation) in mitotic human DIPG and mouse tumor cells. "
05/20/2015 - "However, due to the generous participation of DIPG families in programs for postmortem specimen donation, there has been a recent surge in molecular analysis of newly available tumor specimens. "
|3.||Brain Neoplasms (Brain Tumor)
07/01/2013 - "DIPG is among the most devastating brain tumors in children, necessitating the development of novel treatment strategies and advanced imaging markers such as perfusion to adequately monitor clinical trials. "
01/01/2015 - "DIPG is almost uniformly fatal and is the leading cause of brain tumor-related death in children. "
01/01/2014 - "Despite numerous efforts to improve treatment, DIPG remains incurable with 90% of children dying within 2 y of diagnosis, making it one of the leading causes of death in children with brain tumors. "
10/01/2013 - "DIPG has the worst prognosis among all pediatric brain tumors and the overwhelming majority of patients die within 6-18 months after diagnosis. "
02/01/2012 - "Although DIPG constitute only 10-15% of all pediatric brain tumors, they are the main cause of death in this group. "
08/01/2013 - "BsT in children comprised two different groups: diffuse (DIPG) and focal gliomas. "
08/01/2013 - "DIPG's histology (obtained usually at necropsy) confirmed five high-grade gliomas. "
02/01/2013 - "B7-H3 immunoreactivity was determined in DIPG and non-diffuse brainstem glioma specimens with immunohistochemistry. "
01/01/2013 - "As such, we suggest that alternative ways of drug delivery may offer new possibilities for the treatment of pediatric high-grade glioma patients, and DIPG in particular."
01/01/2013 - "Therefore, we performed an in vitro drug screen on primary glioma cells, including three DIPG cultures, to determine drug sensitivity of these tumours, without the possible confounding effect of insufficient drug delivery. "
|5.||Glioblastoma (Glioblastoma Multiforme)
01/01/2014 - "To test this hypothesis, we performed immunohistochemical studies to compare epigenetic alterations in DIPG to extrapontine adult and pediatric glioblastoma (GBM) and normal brain. "
10/20/2011 - "Single-nucleotide polymorphism arrays were used to compare the frequencies of genomic copy number abnormalities in 43 DIPGs and eight low-grade brainstem gliomas with data from adult and pediatric (non-DIPG) glioblastomas, and expression profiles were evaluated using gene expression arrays for 27 DIPGs, six low-grade brainstem gliomas, and 66 nonbrainstem low-grade gliomas. "
01/01/2016 - "In addition, we were able to discern the H3F3A K27M mutation in a newly obtained pediatric brainstem glioblastoma sample whose H3.3 status was not known previously, and in three other DIPG samples as well as paraffin embedded samples. "
10/01/2015 - "The drug may also be useful in glioblastoma (GBM) and diffuse intrinsic pontine gliomas (DIPG), which often have an activated CDK4/6-retinoblastoma signaling pathway. "
09/01/2012 - "Pediatric glioblastomas (GBM) including diffuse intrinsic pontine gliomas (DIPG) are devastating brain tumors with no effective therapy. "
|3.||Proteins (Proteins, Gene)
|4.||dasatinib (BMS 354825)
|5.||N- (4- bromo- 2- fluorophenyl)- 6- methoxy- 7- ((1- methylpiperidin- 4- yl)methoxy)quinazolin- 4- amine (ZD6474)
|6.||Vascular Endothelial Growth Factor Receptor-2 (Vascular Endothelial Growth Factor Receptor 2)
|7.||Messenger RNA (mRNA)
|9.||Vascular Endothelial Growth Factor Receptors (VEGF Receptors)
|10.||Activin Receptors (Activin Receptor)
|2.||Drug Therapy (Chemotherapy)
|3.||Heterologous Transplantation (Xenotransplantation)
|5.||Homologous Transplantation (Allograft)