|1.||Widdop, Robert E: 4 articles (11/2013 - 04/2009)|
|2.||Vinh, Antony: 3 articles (11/2013 - 04/2009)|
|3.||Jones, Emma S: 2 articles (11/2013 - 01/2012)|
|4.||Gao, Lie: 2 articles (10/2013 - 10/2008)|
|5.||Callaway, Jennifer K: 2 articles (12/2012 - 04/2009)|
|6.||Sobey, Christopher G: 2 articles (12/2012 - 01/2012)|
|7.||McCarthy, Claudia A: 2 articles (12/2012 - 04/2009)|
|8.||Gong, Wan-kun: 1 article (02/2015)|
|9.||Wang, Bin: 1 article (02/2015)|
|10.||Huang, Hong-ping: 1 article (02/2015)|
12/01/2012 - "CGP42112 given over 4 doses in the same rats (3 µg/kg per dose centrally) at 6, 24, 48, and 72 hours after stroke induction reduced total infarct volume (32 ± 13 mm(3) versus vehicle, 170 ± 49 mm(3); P<0.05) and improved motor function. "
12/01/2012 - "Intracerebroventricular administration of the AT(2)R agonist CGP42112 was commenced 6 hours after an ischemic stroke had been induced in conscious spontaneously hypertensive rats. "
04/01/2009 - "Therefore, we have examined the neuroprotective effect of AT(2)R stimulation after intracerebroventricular administration of AT(2)R agonist CGP42112 in a conscious rat model of stroke. "
01/01/2012 - " Intracerebral administration of the angiotensin II type 2 receptor (AT2R) agonist, CGP42112, is neuroprotective in a rat model of ischemic stroke. "
04/01/2009 - "Spontaneously hypertensive rats were treated with either CGP42112 (0.1 to 10 ng/kg/min intracerebroventricularly) alone or in combination with the AT(2)R antagonist PD123319 (36 ng/kg/min intracerebroventricularly) beginning 5 days before stroke induction. "
12/01/1992 - "CGP 42112A was as effective in preventing neointima formation as perindopril (-73%, p < 0.01, versus -76%, p < 0.01, respectively).(ABSTRACT TRUNCATED AT 250 WORDS)"
12/01/1994 - "CGP 42112A (1 mg/d) did not change the neointima-media ratio, indicating that angiotensin subtype 2 receptors were not involved in myointimal hyperplasia in rabbits. "
|3.||Brain Ischemia (Cerebral Ischemia)
01/01/2012 - "Secondly, we tested whether CGP42112 is effective when administered systemically in a mouse model of cerebral ischemia. "
01/01/2012 - "Mice treated with CGP42112 (1 mg/kg i.p.) after cerebral ischemia had improved functional outcomes over vehicle-treated mice as well as reduced total and cortical infarct volumes. "
01/01/2012 - "Furthermore, systemic administration of CGP42112 can reduce functional deficits and infarct volume following cerebral ischemia in vivo."
|4.||Wounds and Injuries (Trauma)
09/26/1994 - "We characterized a novel non-angiotensin II binding site that is recognized by the angiotensin II AT2 receptor ligand [125I]CGP 42112, in healing brain wounds of adult rats. "
09/26/1994 - "Expression of a novel non-angiotensin II [125I]CGP 42112 binding site in healing wounds of the rat brain."
07/01/2006 - "1. During the course of studies directed to determine the transport of Angiotensin II AT(2) receptors in the rat brain, we found that stab wounds to the brain revealed a binding site recognized by the AT(2) receptor ligand CGP42112 but not by Angiotensin II. 2. We localized this novel site to macrophages/microglia associated with physical or chemical injuries of the brain. "
03/01/2011 - "Therefore, in the present study, we tested the effects of the AT(2) receptor agonist CGP-42112A on inflammation and oxidative stress in obese Zucker rats and compared them in their lean counterparts. "
03/01/2011 - "Rats were systemically treated with either vehicle (control) or CGP-42112A (1 μg·kg(-1)·min(-1); osmotic pump) for 2 wk. Markers of inflammation (CRP, MCP-1, TNF-α, and IL-6) and oxidative stress (HO-1, gp-91(phox)) as well as an antioxidant (SOD) were determined. "
10/01/2007 - "Inflammation was induced with platelet activating factor (PAF), and L(p) was measured during perfusion of AngII with AT1 blockade and also with an AT2 receptor agonist, CGP42112. "
|5.||NG-Nitroarginine Methyl Ester (L-NAME)
|7.||Type 2 Angiotensin Receptor
|8.||Nitric Oxide Synthase (NO Synthase)
|9.||Arachidonic Acid (Vitamin F)
|10.||1-Methyl-4-phenylpyridinium (1 Methyl 4 phenylpyridinium)