|1.||Gershwin, M Eric: 5 articles (01/2013 - 05/2005)|
|2.||Coppel, Ross L: 4 articles (01/2013 - 05/2005)|
|3.||Ansari, Aftab A: 4 articles (01/2013 - 05/2005)|
|4.||Leung, Patrick S C: 4 articles (11/2011 - 05/2005)|
|5.||Ansari, A A: 3 articles (08/2014 - 10/2011)|
|6.||Leung, P S C: 3 articles (08/2014 - 10/2011)|
|7.||Gershwin, M E: 3 articles (08/2014 - 10/2011)|
|8.||Tsuneyama, Koichi: 3 articles (01/2013 - 08/2008)|
|9.||Kurth, Mark J: 3 articles (11/2011 - 05/2005)|
|10.||Yang, Guo-Xiang: 2 articles (01/2013 - 08/2008)|
01/01/2013 - "Herein we have taken advantage of our unique model of murine PBC in which mice immunized with 2-octynoic acid coupled to BSA (2OA-BSA), a compound identified by quantitative structure activity relationships (QSAR) of human AMA binding, develop an intense inflammatory cholangitis with striking similarities to humans with PBC. "
08/01/2014 - "In this study we have taken advantage of our ability to induce autoimmune cholangitis with 2-octynoic acid, a common component of cosmetics, conjugated to bovine serum albumin (2-OA-BSA), and studied the natural history of pathology in mice genetically deleted for CD4 or CD8 following immunization with 2-OA-BSA in the presence or absence of α-galactosylceramide (α-GalCer). "
11/01/2011 - "Importantly, we have demonstrated that murine immunization with one such mimic, 2-octynoic acid coupled to bovine serum albumin (BSA), induces anti-mitochondrial antibodies (AMAs) and cholangitis. "
10/01/2011 - "Our laboratory has studied a murine model of autoimmune cholangitis induced following immunization with 2-octynoic acid (2OA), an antigen identified following extensive quantitative structural activity relationship (QSAR) analysis, using human autoantibodies and three-dimensional analysis of the mitochondrial autoantigen, the E2 subunit of the pyruvate dehydrogenase complex (PDC-E2). "
08/01/2008 - "Mice immunized with 2-octynoic acid manifest autoimmune cholangitis, typical mitochondrial autoantibodies, increased liver lymphoid cell numbers, an increase in CD8(+) liver infiltrating cells, particularly CD8(+) T cells that coexpress CD44, and finally an elevation of serum tumor necrosis factor-alpha and interferon-gamma. "
|2.||Biliary Liver Cirrhosis (Primary Biliary Cirrhosis)
03/01/2011 - "Our laboratory has developed a xenobiotic induced model of primary biliary cirrhosis (PBC) following immunization of mice with 2-octynoic acid coupled to bovine serum albumin (2-OA-BSA), an antigen selected following quantitative structure-activity relationship analysis of the E2 subunit of the pyruvate dehydrogenase complex (PDC-E2), the immunodominant autoantigen of PBC. "
05/01/2005 - "Chemical xenobiotics and mitochondrial autoantigens in primary biliary cirrhosis: identification of antibodies against a common environmental, cosmetic, and food additive, 2-octynoic acid."
01/01/2013 - "The effect of 2-octynoic acid (2-OA) on HCV infection in human hepatocytes was examined. "
01/01/2013 - "2-octynoic acid inhibits hepatitis C virus infection through activation of AMP-activated protein kinase."
11/01/1990 - "As to unsaturated acids, those with eight carbon atoms, 2-octenoic acid (trans-8: 1) and 2-octynoic acid (8:::1), increase the susceptibility to infection and fluidity while low concentrations of monounsaturated acids with 14 and 18 carbon atoms, myristoleic acid (cis-14:1) and oleic acid (cis-18:1), reduce both the susceptibility to infection and the fluidity of the membrane."
06/01/2012 - "In particular, following immunization with 2-octynoic acid (a synthetic chemical mimic of lipoic acid-lysine located within the inner domain of PDC-E2) coupled to bovine serum albumin (BSA), several strains of mice develop typical anti-mitochondrial autoantibodies and portal inflammation. "
|1.||Bovine Serum Albumin
|4.||Pyruvate Dehydrogenase Complex (Dehydrogenase Complex, Pyruvate)
|8.||AMP-Activated Protein Kinases
|9.||Oleic Acid (Oleate)