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2-octynoic acid

structure given in first source
Networked: 10 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Experts

1. Gershwin, M Eric: 5 articles (01/2013 - 05/2005)
2. Coppel, Ross L: 4 articles (01/2013 - 05/2005)
3. Ansari, Aftab A: 4 articles (01/2013 - 05/2005)
4. Leung, Patrick S C: 4 articles (11/2011 - 05/2005)
5. Ansari, A A: 3 articles (08/2014 - 10/2011)
6. Leung, P S C: 3 articles (08/2014 - 10/2011)
7. Gershwin, M E: 3 articles (08/2014 - 10/2011)
8. Tsuneyama, Koichi: 3 articles (01/2013 - 08/2008)
9. Kurth, Mark J: 3 articles (11/2011 - 05/2005)
10. Yang, Guo-Xiang: 2 articles (01/2013 - 08/2008)

Related Diseases

1. Cholangitis
01/01/2013 - "Herein we have taken advantage of our unique model of murine PBC in which mice immunized with 2-octynoic acid coupled to BSA (2OA-BSA), a compound identified by quantitative structure activity relationships (QSAR) of human AMA binding, develop an intense inflammatory cholangitis with striking similarities to humans with PBC. "
08/01/2014 - "In this study we have taken advantage of our ability to induce autoimmune cholangitis with 2-octynoic acid, a common component of cosmetics, conjugated to bovine serum albumin (2-OA-BSA), and studied the natural history of pathology in mice genetically deleted for CD4 or CD8 following immunization with 2-OA-BSA in the presence or absence of α-galactosylceramide (α-GalCer). "
11/01/2011 - "Importantly, we have demonstrated that murine immunization with one such mimic, 2-octynoic acid coupled to bovine serum albumin (BSA), induces anti-mitochondrial antibodies (AMAs) and cholangitis. "
10/01/2011 - "Our laboratory has studied a murine model of autoimmune cholangitis induced following immunization with 2-octynoic acid (2OA), an antigen identified following extensive quantitative structural activity relationship (QSAR) analysis, using human autoantibodies and three-dimensional analysis of the mitochondrial autoantigen, the E2 subunit of the pyruvate dehydrogenase complex (PDC-E2). "
08/01/2008 - "Mice immunized with 2-octynoic acid manifest autoimmune cholangitis, typical mitochondrial autoantibodies, increased liver lymphoid cell numbers, an increase in CD8(+) liver infiltrating cells, particularly CD8(+) T cells that coexpress CD44, and finally an elevation of serum tumor necrosis factor-alpha and interferon-gamma. "
2. Biliary Liver Cirrhosis (Primary Biliary Cirrhosis)
3. Infection
4. Inflammation

Related Drugs and Biologics

1. Bovine Serum Albumin
2. Cosmetics
3. Autoantibodies
4. Pyruvate Dehydrogenase Complex (Dehydrogenase Complex, Pyruvate)
5. Antigens
6. Antibodies
7. tebufenozide (Mimic)
8. AMP-Activated Protein Kinases
9. Oleic Acid (Oleate)
10. Xenobiotics