factor IX Troed-y-Rhiw
substitution of Glu for Arg at position 4 of the propeptide which blocks cleavage between Arg145-Ala146 in the activator peptide and leads to circulation of the mutant factor with the propeptide still attached; abolishes HaeIII restriction enzyme recognition & impairs calcium binding
Networked: 0
relevant articles (0 outcomes,
0 trials/studies)
Bio-Agent Context: Research Results