Sch 39370

RN given refers to (D)-hydroxy-isomer; RN for cpd without isomeric designation not available 9/89; structure given in first source; inhibits neutral metalloendopeptidase

Also Known As:

N-(N-(1-carboxyl-3-phenylpropyl)-Phe)-iso-Ser; N-(N-(1-carboxyl-3-phenylpropyl)phenylalanyl)isoserine; Sch 39370, L-OH-isomer; Sch-39370

Networked: 4 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Peptides: 82426
  - Oligopeptides: 519
    - Dipeptides: 945
      - Sch 39370: 4

Related Diseases

1.	Hypertension (High Blood Pressure) 07/01/1995 - "To assess the efficacy of neutral endopeptidase 24.11 inhibition in the setting of elevated plasma levels of angiotensin II (Ang II), we studied the hemodynamic, renal, and hormonal effects of bolus injections of the potent and specific neutral endopeptidase inhibitor SCH 39370 or vehicle (control) in 10 sheep with Ang II-induced hypertension. "
2.	Heart Failure 05/30/1991 - "HPLC revealed only intact ANP in plasma of rats with heart failure during SCH 39370 treatment. " 05/30/1991 - "We studied the hormonal, renal and hemodynamic effects of prolonged treatment with SCH 39370, a new neutral endopeptidase (NEP) inhibitor, in experimental congestive heart failure (CHF). " 05/01/1992 - "1. The acute hormonal, renal and haemodynamic effects of SCH 39370, a new neutral endopeptidase (NEP) inhibitor, were evaluated in rats with congestive heart failure (CHF) produced by coronary ligation. " 05/30/1991 - "In rats with heart failure, SCH 39370 elevated the high plasma atrial natriuretic peptide (ANP) and cyclic guanosine monophosphate (cGMP) levels 2-fold both initially and at the end of the experiment. " 08/01/1990 - "Elevation of plasma atrial natriuretic peptide in rats with chronic heart failure by SCH 39370, a neutral metalloendopeptidase inhibitor."

Related Drugs and Biologics

1.	Neprilysin (Neutral Endopeptidase)
2.	Angiotensin II
3.	Atrial Natriuretic Factor (ANF)
4.	Metalloendopeptidases (Metalloendopeptidase)
5.	Guanosine Monophosphate (5' Guanylic Acid)

Related Therapies and Procedures

1.	Injections
2.	Ligation