|1.||Spiegel, Sarah: 31 articles (12/2015 - 09/2002)|
|2.||Milstien, Sheldon: 25 articles (12/2015 - 09/2002)|
|3.||Obeid, Lina M: 18 articles (11/2015 - 04/2007)|
|4.||Natarajan, Viswanathan: 16 articles (12/2015 - 08/2002)|
|5.||Pyne, Nigel J: 16 articles (05/2014 - 02/2010)|
|6.||Garcia, Joe G N: 15 articles (12/2015 - 08/2002)|
|7.||Pyne, Susan: 15 articles (05/2014 - 02/2010)|
|8.||Takabe, Kazuaki: 14 articles (12/2015 - 08/2008)|
|9.||Cuvillier, Olivier: 14 articles (11/2015 - 12/2005)|
|10.||Yatomi, Yutaka: 14 articles (01/2015 - 04/2003)|
06/26/2014 - "Sphingosine 1-phosphate (S1P) lyase has recently been implicated as a therapeutic target for the treatment of multiple sclerosis (MS), based on studies in a genetic mouse model. "
06/26/2014 - "Modulation of sphingosine 1-phosphate (S1P) signaling represents a solid opportunity for multiple sclerosis (MS) treatment. "
06/26/2014 - "The first sphingosine 1-phosphate lyase inhibitors against multiple sclerosis: a successful drug discovery tale."
06/26/2014 - "Orally active 7-substituted (4-benzylphthalazin-1-yl)-2-methylpiperazin-1-yl]nicotinonitriles as active-site inhibitors of sphingosine 1-phosphate lyase for the treatment of multiple sclerosis."
01/01/2013 - "Efficacy and immunomodulatory actions of ONO-4641, a novel selective agonist for sphingosine 1-phosphate receptors 1 and 5, in preclinical models of multiple sclerosis."
07/15/2009 - "Several experimental studies have demonstrated protection against cardiac ischaemia-reperfusion injury achieved by pre-treatment with exogenous sphingosine-1-phosphate (S1P). "
04/01/2014 - "Selective deletion of the endothelial sphingosine-1-phosphate 1 receptor exacerbates kidney ischemia-reperfusion injury."
09/01/2012 - "Dendritic cell sphingosine 1-phosphate receptor-3 regulates Th1-Th2 polarity in kidney ischemia-reperfusion injury."
01/01/2011 - "We also summarize the present state of knowledge on the involvement of ceramide and sphingosine-1-phosphate in the development and prevention of ischemia/reperfusion injury of the heart. "
06/01/2010 - "Activation of sphingosine-1-phosphate 1 receptor in the proximal tubule protects against ischemia-reperfusion injury."
|3.||Experimental Autoimmune Encephalomyelitis (Encephalomyelitis, Autoimmune Experimental)
01/01/2014 - "ASP4058, a novel agonist for sphingosine 1-phosphate receptors 1 and 5, ameliorates rodent experimental autoimmune encephalomyelitis with a favorable safety profile."
03/30/2012 - "In experimental autoimmune encephalomyelitis--an animal model of multiple sclerosis--fingolimod blocks the sphingosine-1-phosphate gradient controlled lymphocyte egress from the lymph nodes and therefore reduces the peripheral lymphocyte count especially the encephalitogenic Th17 subset is reduced. "
03/01/2011 - "Fingolimod (FTY720), a sphingosine 1-phosphate (S1P) receptor modulator, inhibits S1P-dependent lymphocyte egress from secondary lymphoid organs and is highly effective in experimental autoimmune encephalomyelitis (EAE) in mice. "
12/01/2014 - "Vitamin D therapy in experimental allergic encephalomyelitis could be limited by opposing effects of sphingosine 1-phosphate and gelsolin dysregulation."
12/27/2013 - "Studies in cell culture and mouse models of cancer have indicated that the soluble sphingolipid metabolite sphingosine 1-phosphate (S1P) promotes cancer cell proliferation, survival, invasiveness, and tumor angiogenesis. "
04/01/2010 - "The aims of this study are to examine the effect of sphingosine 1-phosphate (S1P) on IL-2-activated natural killer (NK) cell lysis of K562 tumor cells and immature dendritic cells (iDCs), and to investigate the mechanisms involved in S1P activity. "
09/01/2015 - "This particular intervention slows ceramide destruction and thereby depresses formation of sphingosine 1-phosphate, a mitogenic sphingolipid with cancer growth-promoting properties. "
08/04/2015 - "As an enzyme regulating the balance of ceramide and sphingosine-1-phosphate, nCDase is emerging as a therapeutic target for cancer. "
08/01/2015 - "Sphingosine 1-phosphate interacts with Survivin pathway to enhance tumorigenesis in cancer cells."
01/01/2014 - "The present study investigates the preclinical efficacy of sphingosine-1-phosphate (S1P) to improve acclimatization to simulated hypobaric hypoxia. "
07/01/2011 - "This study aimed to identify receptors mediating sphingosine-1-phosphate (S1P)-induced vasoconstriction in the normotensive and chronic hypoxia-induced hypertensive rat pulmonary circulation. "
11/01/2015 - "[Sphingomab(TM), an anti-sphingosine 1-phosphate antibody to inhibit hypoxia]."
01/01/2015 - "Hypoxia augments outgrowth endothelial cell (OEC) sprouting and directed migration in response to sphingosine-1-phosphate (S1P)."
11/01/2014 - "Hypoxia also increases sphingosine-1-phosphate and the activity of glucosylceramide (Glc-Cer) synthase. "
|7.||Interleukin-10 (Interleukin 10)
|1.||Transplantation (Transplant Recipients)
|2.||Drug Therapy (Chemotherapy)
|3.||Artificial Respiration (Mechanical Ventilation)