EAP protocol

chemotherapy protocol consisting of the above cpds; used in treatment of patients with advanced gastric carcinoma

Also Known As:

DPE protocol; PAV regimen

Networked: 5 relevant articles (3 outcomes, 1 trials/studies)

Relationship Network

Therapy Context: Research Results

Therapeutics: 1158551
- Drug Therapy: 293145
  - Combination Drug Therapy: 12066
    - Antineoplastic Combined Chemotherapy Protocols: 35
      - EAP protocol: 5
  - Antineoplastic Protocols: 55
    - Antineoplastic Combined Chemotherapy Protocols: 35
      - EAP protocol: 5
- Clinical Protocols
  - Antineoplastic Protocols: 55
    - Antineoplastic Combined Chemotherapy Protocols: 35
      - EAP protocol: 5
Inorganic Chemicals: 9
Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Aromatic Hydrocarbons: 291
      - Polycyclic Aromatic Hydrocarbons: 2020
        Naphthalenes: 18
        Tetrahydronaphthalenes: 1
        Podophyllotoxin: 562
        Etoposide: 10706
        EAP protocol: 5
        Naphthacenes
        Anthracyclines: 9423
        Daunorubicin: 2641
        Doxorubicin: 35390
        EAP protocol: 5
Polycyclic Compounds: 6
- Polycyclic Aromatic Hydrocarbons: 2020
  - Naphthalenes: 18
    - Tetrahydronaphthalenes: 1
      - Podophyllotoxin: 562
        Etoposide: 10706
        EAP protocol: 5
  - Naphthacenes
    - Anthracyclines: 9423
      - Daunorubicin: 2641
        Doxorubicin: 35390
        EAP protocol: 5
Carbohydrates: 22023
- Glycosides: 2119
  - Aminoglycosides: 5131
    - Anthracyclines: 9423
      - Daunorubicin: 2641
        Doxorubicin: 35390
        EAP protocol: 5
  - Glucosides: 639
    - Etoposide: 10706
      - EAP protocol: 5

Experts

1.	Altomonte, Maresa: 1 article (10/2013)
2.	Ascierto, Paolo: 1 article (10/2013)
3.	Bajetta, Emilio: 1 article (10/2013)
4.	Calabrò, Luana: 1 article (10/2013)
5.	Chiarion-Sileni, Vanna: 1 article (10/2013)
6.	Danielli, Riccardo: 1 article (10/2013)
7.	Di Giacomo, Anna: 1 article (10/2013)
8.	Ferrucci, Pier: 1 article (10/2013)
9.	Giannarelli, Diana: 1 article (10/2013)
10.	Maio, Michele: 1 article (10/2013)

Related Diseases

1.	Neoplasms (Cancer) 03/01/2001 - "We have tested the feasibility, tolerability, and efficacy of a multimodality treatment approach for patients with locally advanced cancer of the upper gastrointestinal tract including preoperative chemotherapy with the EAP-protocol as induction and a consecutive high-dose chemotherapy with MCVB and autologous stem cell rescue for responding patients. " 08/01/2006 - "The PAV regimen is effective against MGMT-methylated malignant astrocytomas, but the CE regimen is not useful at the given dose and schedule in MGMT-unmethylated tumors." 10/01/1996 - "The purpose of this trial was to test feasibility and tolerability of a multimodality treatment approach for patients with tumors in the upper gastrointestinal tract (EC, esophageal cancer; JC, cancer of the gastro-esophageal junction; GC, gastric cancer) including preoperative chemotherapy with the EAP-protocol as induction and a consecutive high-dose-chemotherapy for responding patients. " 08/01/2006 - "The procarbazine, 1-(4-amino-2-methyl-5-pyrimidinyl)methyl-3-2(2-chloroethyl)-3-nitrosourea, and vincristine (PAV) regimen was administered to seven patients with MGMT-methylated tumors, and the carboplatin and etoposide (CE) regimen was administered to 13 patients with MGMT-unmethylated tumors. "
2.	Melanoma (Melanoma, Malignant) 10/01/1983 - "The result indicates that PAV regimen is useful for the treatment of malignant melanoma since toxic reactions were mild. " 10/25/2013 - "As per the EAP protocol, patients had life-threatening, unresectable stage III/IV melanoma, had failed or did not tolerate previous treatments and had no other therapeutic option available. "
3.	Astrocytoma (Pilocytic Astrocytoma) 08/01/2006 - "The PAV regimen is effective against MGMT-methylated malignant astrocytomas, but the CE regimen is not useful at the given dose and schedule in MGMT-unmethylated tumors."
4.	Stomach Neoplasms (Stomach Cancer) 10/01/1996 - "The purpose of this trial was to test feasibility and tolerability of a multimodality treatment approach for patients with tumors in the upper gastrointestinal tract (EC, esophageal cancer; JC, cancer of the gastro-esophageal junction; GC, gastric cancer) including preoperative chemotherapy with the EAP-protocol as induction and a consecutive high-dose-chemotherapy for responding patients. "
5.	Esophageal Neoplasms (Esophageal Cancer) 10/01/1996 - "The purpose of this trial was to test feasibility and tolerability of a multimodality treatment approach for patients with tumors in the upper gastrointestinal tract (EC, esophageal cancer; JC, cancer of the gastro-esophageal junction; GC, gastric cancer) including preoperative chemotherapy with the EAP-protocol as induction and a consecutive high-dose-chemotherapy for responding patients. "

Related Drugs and Biologics

1.	Carboplatin (JM8)
2.	Vincristine (Oncovin)
3.	Procarbazine (Matulane)
4.	Etoposide (VP 16)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	JET protocol