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cytotoxic necrotizing factor type 1

from E coli; MW 115kDa; associated with both cytotoxicity & in vivo toxicity; present in all presumed CNF-producing strains; two types of CNFs have been described CNF1 & CNF2
Also Known As:
CNF1, bacterial; bacterial CNF1; cytotoxic necrotizing factor 1
Networked: 36 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Experts

1. Fiorentini, Carla: 3 articles (01/2015 - 01/2014)
2. Kim, Kwang Sik: 3 articles (11/2013 - 06/2011)
3. Ballan, Giulia: 2 articles (01/2015 - 08/2014)
4. Guidotti, Marco: 2 articles (01/2015 - 08/2014)
5. Travaglione, Sara: 2 articles (01/2015 - 08/2014)
6. Loizzo, Stefano: 2 articles (01/2015 - 08/2014)
7. Fabbri, Alessia: 2 articles (08/2014 - 01/2014)
8. Yu, Hao: 2 articles (03/2012 - 06/2011)
9. O'Brien, A D: 2 articles (10/2001 - 10/2000)
10. Weingarten, Rebecca A: 1 article (04/2015)

Related Diseases

1. Urinary Tract Infections (Urinary Tract Infection)
09/03/2001 - "In this study, a total of 118 Escherichia coli strains isolated from dogs (93) and cats (25) with urinary tract infection (UTI) were tested in a multiplex polymerase chain reaction for the presence of adhesin-encoding genes (pap, sfa, and afa), hemolysin encoding genes (hly), cytotoxic necrotizing factor 1 (cnf1) and aerobactin (aer) genes. "
09/01/2002 - "coli isolates from urine or vaginal or rectal swabs of patients with recurrent urinary tract infection were screened for P fimbria (pap), hemolysin (hly), aerobactin (aer), cytotoxic necrotizing factor 1 (cnf1), S fimbria (sfa), and afimbrial adhesion I (afaI) genes by multiplex PCR. "
04/01/2015 - "Antibodies against hemolysin and cytotoxic necrotizing factor type 1 (CNF1) reduce bladder inflammation in a mouse model of urinary tract infection with toxigenic uropathogenic Escherichia coli."
09/01/2008 - "Adhesins (P-fimbriae, S-fimbriae, type 1 fimbriae and afimbrial adhesin), toxins (alpha-hemolysin and cytotoxic necrotizing factor type 1), iron acquisition systems (aerobactin) and host defense avoidance mechanisms (capsule or lipopolysaccharide) have been shown to be prevalent in Escherichia coli strains associated with urinary tract infections. "
10/01/2000 - "Pathogenic Escherichia coli associated with urinary tract infections (UTIs) in otherwise healthy individuals frequently produce cytotoxic necrotizing factor type 1 (CNF1), a member of the family of bacterial toxins that target the Rho family of small GTP-binding proteins. "
2. Infection
3. Pyelonephritis
10/01/1999 - "To assess the urovirulence characteristics of Escherichia coli strains causing acute prostatitis, urinary isolates from men with acute prostatitis (n=107) and from women with acute uncomplicated pyelonephritis (n=76) were examined for the prevalence of sfa, foc, and 3 papG allele genotypes and phenotypes and for the production of alpha-hemolysin and cytotoxic necrotizing factor 1. The papG allele III and foc gene were found more frequently and the papG allele II less frequently among prostatitis than from pyelonephritis isolates. "
08/01/1998 - "coli simultaneously possessed the genes encoding the class III P fimbrial adhesin (prsG(J96)), alpha-hemolysin and cytotoxic necrotizing factor 1. Statistical analysis showed the class II P fimbrial adhesin (papG(IA2)) and F1C fimbria to be associated with high relative virulence in pyelonephritis and cystitis, respectively. "
01/01/2013 - "A total of 145 Escherichia coli strains causing pyelonephritis in children were investigated for the prevalence of genes encoding the following virulence factors (VFs): P fimbria (67.6 %), S fimbria (53.8 %), AFA adhesins (2.8 %), cytotoxic necrotizing factor 1 (37.9 %), α-hemolysin (41.4 %), and aerobactin (71.7 %). "
03/01/1998 - "A variety of virulence factors (VFs) such as type 1 fimbriae, pilus associated with pyelonephritis, S fimbriae, afimbrial adhesin, alpha-hemolysin, aerobactin and cytotoxic necrotizing factor 1 are associated with uropathogenic Escherichia coli. "
10/01/1995 - "Primers to amplify the genes encoding the virulence factors of uropathogenic Escherichia coli, such as pilus associated with pyelonephritis (pap), haemolysin (hly), aerobactin (aer) and cytotoxic necrotizing factor 1 (cnf1) genes, were designed. "
4. Meningitis
5. Cystitis

Related Drugs and Biologics

1. aerobactin
2. Virulence Factors (Pathogenicity Factors)
3. A-Form DNA (A-DNA)
4. Carboxylesterase (Hydrolase S)
5. Shiga Toxin (Shigella Toxin)
6. GTP Phosphohydrolases (GTPases)
7. GTP-Binding Proteins (G-Protein)
8. O Antigens (O Antigen)
9. RNA (Ribonucleic Acid)
10. Neurotoxins