|1.||Dong, X: 2 articles (08/2015 - 01/2011)|
|2.||Calixto, João B: 2 articles (11/2010 - 08/2006)|
|3.||Shen, E: 2 articles (04/2008 - 09/2007)|
|4.||Peng, Tianqing: 2 articles (04/2008 - 09/2007)|
|5.||Fan, Jue: 2 articles (04/2008 - 09/2007)|
|6.||Wang, Xiaofang: 1 article (10/2015)|
|7.||Liu, Fang: 1 article (10/2015)|
|8.||Zheng, Yanqian: 1 article (10/2015)|
|9.||Jin, Zhu: 1 article (10/2015)|
|10.||Zhang, Wenhui: 1 article (10/2015)|
11/02/2001 - "The phospholipase C inhibitor U73122 prevented FBP-induced increases in [Ca2+]i and eliminated FBP's ability to stabilize [Ca2+]i and increase survival during anoxia. "
02/01/2013 - "Hypoxia remarkably increases inositol 1,4,5-trisphosphate (IP(3)) production, which is blocked by U73122. "
12/31/2008 - "Suramin and U73122 attenuated the hypoxia-induced [Ca2+]i elevation, implying the involvement of the G-protein and PLC pathways in the hypoxic response. "
01/01/2011 - "Moreover, the effects of OAG, the DAG kinase inhibitor R59949 and the phospholipase C inhibitor U73122 on the strength of HPV were investigated compared to those on non-hypoxia-induced vasoconstriction elicited by the thromboxane mimeticum U46619. "
07/01/2010 - "We found that hypoxia-induced EGFR activation and cell migration could be prevented by targeting EGFR signaling with the tyrosine kinase inhibitor tyrphostin, the phospholipase C inhibitor U73122, or by inhibiting the expression of the alpha subunit of hypoxia-inducible factor 2 via RNA interference or the topoisomerase II inhibitor etoposide. "
|2.||Pemphigus (Pemphigus Vulgaris)
09/01/1995 - "However, pre-incubation with U73122 (1-10 microM), but not with U73343 (10 microM), dramatically reduced the pemphigus IgG-induced increases in [Ca++]i, IP3, and PA activity and inhibited the pemphigus IgG-induced cell-cell detachment. "
09/01/1995 - "To clarify whether phospholipase C is involved in this process after the antibody binds to the cell surface, we examined the effects of a specific phospholipase C inhibitor (U73122) on the pemphigus IgG-induced increase in [Ca++]i, IP3, PA secretion, and cell-cell detachment in DJM-1 cells. "
08/01/1999 - "We determined the effects of PLCgamma signal abrogation by pharmacological (U73122) and molecular (expression of the dominant-negative PLCz) means on the in vitro invasiveness of tumor cells. "
09/01/1996 - "To determine whether cell motility may be, in part, responsible for tumor invasiveness, we treated WT DU-145 intraperitoneal tumors with a pharmacologic agent (U73122) which blocks EGFR-mediated cell motility but not mitogenesis. "
08/01/1999 - "To determine whether this signaling pathway also promotes invasiveness of ErbB2-overexpressing tumors, we examined the human breast carcinoma line MDA-361; again, U73122 inhibition of PLCgamma decreased invasiveness. "
09/01/2006 - "Furthermore, we demonstrate that U-73122 can inhibit telomerase in hematopoietic cancer cells. "
10/01/2001 - "Orexins A and B (10(-8) mol/liter) increased IP3, but not cAMP production, by tumor slices, and the effect was blocked by the PLC inhibitor U-73122. "
|5.||Breast Neoplasms (Breast Cancer)
05/01/2014 - "In this study, we sought to observe the effect of knocking down SOCS7 gene on breast cancer cells in vitro growth and migration and to elucidate whether this involves IGF-I-PLCγ1 route using the PLCγ-1 blocker U73122. "
01/01/2014 - "Here, we report our observations of the effect of knocking down SOCS7 gene on the behaviour of breast cancer cells both in vitro and in vivo and to elucidate whether this involves HGF/C-MET pathway using the PLCγ-1 blocker U73122. "
|1.||Type C Phospholipases
|2.||Immunoglobulin G (IgG)
|5.||GTP-Binding Proteins (G-Protein)
|7.||1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester