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Ala(2)- deltorphin II

isolated from skin extracts of frogs belonging to the genus Phyllomedusa; has affinity to opioid receptors
Also Known As:
deltorphin II, Ala(2)-; (Ala(2))deltorphin II; (Ala(2),Glu(4))deltorphin; 2-Ala-4-Glu-deltorphin; DELT II; DELT-II; Tyr-Ala-Phe-Glu-Val-Val-Gly-NH2; deltorphin II; deltorphin, Ala(2)-Glu(4)-; deltorphin, alanyl(2)-glutamyl(4)-; deltorphin-II
Networked: 37 relevant articles (2 outcomes, 5 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Gendron, L: 3 articles (06/2011 - 12/2007)
2. Maslov, L N: 3 articles (10/2010 - 11/2005)
3. Solenkova, N V: 3 articles (10/2010 - 11/2005)
4. Lishmanov, Yury B: 2 articles (01/2014 - 05/2009)
5. Maslov, Leonid N: 2 articles (01/2014 - 05/2009)
6. Oeltgen, Peter R: 2 articles (01/2014 - 05/2009)
7. Barzakh, Eva I: 2 articles (01/2014 - 05/2009)
8. Krylatov, Andrey V: 2 articles (01/2014 - 05/2009)
9. Brown, Stephen A: 2 articles (01/2014 - 05/2009)
10. Krieg, T: 2 articles (10/2010 - 06/2009)

Related Diseases

1. Ventricular Premature Complexes (Premature Ventricular Contraction)
2. Ventricular Tachycardia
3. Bradycardia
4. Pain (Aches)
5. Seizures (Seizure)
01/19/2006 - "The present study examined whether a variety of peptidic delta agonists, DPDPE, JOM-13, a systemically active derivative of DPDPE, deltorphin II, and H-Dmt-Tic-NH-CH2-Bid could produce convulsions and antidepressant-like effects in the forced swim test. "
01/01/2008 - "Finally, GTN on its own (300 microg/icv/toto) significantly increased morphine or deltorphin II seizures in the rabbit and it was also able to reverse the inhibition on morphine or deltorphin II seizures operated by L-NAME. "
01/01/2001 - "Dexamethasone pre-treatment prevented DAMGO-, deltorphin II- and beta-endorphin-induced seizures as well as changes in background EEG, physical parameters and overt behaviour induced by mu-opioid agonists. "
01/01/2008 - "c) Morphine and deltorphin II (100 microg/icv/toto) produce EEG seizure activity in rabbits and L-NAME (300 microg/i.c.v./toto), injected 15 min before morphine or deltorphin II, dose dependently prevented the EEG ictal episodes, the spiking activity and the synchronized EEG pattern induced by morphine or deltorphin II. The inhibitory effect of L-NAME on morphine or deltorphin II seizures was dose-dependently reversed by L-arginine (300 microg/icv/toto) but not by D-arginine. "
01/01/2001 - "We found that the mu- and delta-opioid peptides [D-Ala(2)-N,Me-Phe(4)-Gly(5)-ol]enkephalin (DAMGO), beta-endorphin and deltorphin II, induced EEG non-convulsive hippocampal seizures, and changes in hippocampal background EEG, physical parameters and overt behaviour after central administration. "

Related Drugs and Biologics

1. delta Opioid Receptors (delta Opioid Receptor)
2. D-Penicillamine (2,5)- Enkephalin
3. Morphine (MS Contin)
4. Enkephalins
5. deltorphin
6. (trans)-Isomer 3,4- Dichloro- N- methyl- N- (2- (1- pyrrolidinyl)- cyclohexyl)- benzeneacetamide
7. naltrindole
8. Naltrexone (ReVia)
9. Narcotic Antagonists (Opioid Antagonists)
10. endomorphin 2

Related Therapies and Procedures

1. Injections
2. Resuscitation
3. Analgesia