Ala(2)- deltorphin II

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27 relevant articles (1 outcomes, 4 trials/studies) found for this Bio-Agent

Description: isolated from skin extracts of frogs belonging to the genus Phyllomedusa; has affinity to opioid receptors

Also Known As:

deltorphin II, Ala(2)-; (Ala(2))deltorphin II; (Ala(2),Glu(4))deltorphin; 2-Ala-4-Glu-deltorphin; DELT II; DELT-II; Tyr-Ala-Phe-Glu-Val-Val-Gly-NH2; deltorphin II; deltorphin, Ala(2)-Glu(4)-; deltorphin, alanyl(2)-glutamyl(4)-; deltorphin-II

Relationship Network

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins

Peptides: 16074

Oligopeptides: 165

Ala(2)- deltorphin II: 27

Related Diseases

1.	Bradycardia 10/01/2001 - "When deltorphin II (a delta opioid receptor agonist) was infused into the sinoatrial node, more than 95% of the vagal bradycardia was eliminated at 0.3 nmoles/microL with the half-maximal response near 0.1 nmoles/microL, indicating that deltorphin II was more efficacious than MEAP" Get all the results and reference details, order at left...
2.	Seizures (Seizure) 01/19/2006 - "The present study examined whether a variety of peptidic delta agonists, DPDPE, JOM-13, a systemically active derivative of DPDPE, deltorphin II, and H-Dmt-Tic-NH-CH2-Bid could produce convulsions and antidepressant-like effects in the forced swim test" 01/01/2008 - "Finally, GTN on its own (300 microg/icv/toto) significantly increased morphine or deltorphin II seizures in the rabbit and it was also able to reverse the inhibition on morphine or deltorphin II seizures operated by L-NAME" 01/01/2001 - "Dexamethasone pre-treatment prevented DAMGO-, deltorphin II- and beta-endorphin-induced seizures as well as changes in background EEG, physical parameters and overt behaviour induced by mu-opioid agonists" 01/01/2008 - "c) Morphine and deltorphin II (100 microg/icv/toto) produce EEG seizure activity in rabbits and L-NAME (300 microg/i.c.v./toto), injected 15 min before morphine or deltorphin II, dose dependently prevented the EEG ictal episodes, the spiking activity and the synchronized EEG pattern induced by morphine or deltorphin II. The inhibitory effect of L-NAME on morphine or deltorphin II seizures was dose-dependently reversed by L-arginine (300 microg/icv/toto) but not by D-arginine" 01/01/2001 - "We found that the mu- and delta-opioid peptides [D-Ala(2)-N,Me-Phe(4)-Gly(5)-ol]enkephalin (DAMGO), beta-endorphin and deltorphin II, induced EEG non-convulsive hippocampal seizures, and changes in hippocampal background EEG, physical parameters and overt behaviour after central administration" Get all the results and reference details, order at left...
3.	Pain (Aches) 04/01/2004 - "We compared behavioural responses in two models of acute thermal pain following DPDPE and deltorphin II administration by intracerebroventricular route" 06/13/2003 - "Previous report from our laboratory and other author's study indicated that intrathecal administration of mu agonists morphine and endomorphin-2 and delta-opioid agonist deltorphin II produced a dose-dependent antinociceptive effects in acute and inflammatory pain" 03/09/2001 - "In conclusion, our results show an antiallodynic and antinociceptive action of DPDPE and deltorphin II at the spinal cord level, which suggests that both delta-opioid receptor subtypes play a similar role in neuropathic pain" Get all the results and reference details, order at left...
4.	Hyperphagia 03/01/1997 - "Delt II-induced hyperphagia was significantly reduced by DALCE and NTII, but not naltrexone" 11/01/1998 - "Whereas M6G-induced hyperphagia was insensitive to antisense probes directed against the DOR-1, KOR-1 and KOR-3/ORL1 clones, these probes respectively reduced hyperphagia induced by deltorphin II, U50488H and nociceptin" 03/01/1997 - "The first study assessed the opioid antagonist profile of hyperphagia elicited by centrally administered delta1 ([D-Pen2, D-Pen5]-enkephalin, DPDPE: 5-50 microg) and delta2 ([D-Ala2, Glu4]-Deltorphin, Delt II: 5-50 microg) agonists following central pretreatment with general (naltrexone), delta1 ([D-Ala2, Leu5, Cys6]-enkephalin, DALCE) and delta2 (naltrindole isothiocyanate, NTII) opioid antagonists" Get all the results and reference details, order at left...
5.	Salmonella Infections (Salmonellosis) 03/18/2006 - "The present study compared morphine pellets to morphine pumps and also examined the differential effects of morphine versus U50,488H (kappa agonist), deltorphin II (delta2 agonist), and (D-Pen2, D-Pen5)-enkephalin (DPDPE, delta1 agonist), administered via Alzet minipumps, on oral Salmonella infection and on gastrointestinal transit" Get all the results and reference details, order at left...
19 Diseases and 27 more articles analyzed in the Research Interface, order at left...

Related Drugs and Biologics

1.	delta Opioid Receptors (delta Opioid Receptor)
2.	D-Penicillamine (2,5)- Enkephalin
3.	Morphine (MS Contin)
4.	Enkephalins
5.	(trans)-Isomer 3,4- Dichloro- N- methyl- N- (2- (1- pyrrolidinyl)- cyclohexyl)- benzeneacetamide
6.	deltorphin
7.	naltrindole
8.	Narcotic Antagonists (Opioid Antagonists)
9.	Naltrexone (ReVia)
10.	endomorphin 2
45 Drugs and Important Bio-Agents and 23 more articles analyzed in the Research Interface, order at left...

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