tyrphostin 47

inhibits protein-tyrosine kinase activity of EGF-R both in vitro and in living cells;

Also Known As:

3,4-dihydroxy-alpha-cyanothiocinnamide; 3,4-dihydroxy-alpha-cyanothiocinnamide, (E)-isomer; AG 213; AG-213; AG213; RG 50864; RG-50864; RG50864; alpha-cyano-3,4-dihydroxythiocinnamamide; tyrphostin A47; tyrphostin AG-213; tyrphostin AG213; tyrphostin RG50864

Networked: 11 relevant articles (0 outcomes, 3 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Baltayiannis, Gerasimos: 1 article (11/2016)
2.	Christodoulou, Dimitrios: 1 article (11/2016)
3.	Christou, Leonidas: 1 article (11/2016)
4.	Kalambokis, Georgios N: 1 article (11/2016)
5.	Kolaitis, Nikolaos I: 1 article (11/2016)
6.	Oikonomou, Aikaterini: 1 article (11/2016)
7.	Tsianos, Epameinondas V: 1 article (11/2016)
8.	Gunji, Yasuhiro: 1 article (09/2006)
9.	Horie, Atsuko: 1 article (09/2006)
10.	Ikeda, Masahiro: 1 article (09/2006)

Related Diseases

1.	Asthma (Bronchial Asthma) 10/01/1997 - "The present study was conducted to examine the effects of two protein tyrosine kinase inhibitors, genistein and tyrphostin 47, on an in vitro model of allergic asthma. " 09/01/1999 - "This review summarizes our recent studies on the role of PTK signaling cascade in an in vitro guinea pig model of allergic asthma using PTK inhibitors, genistein and tyrphostin 47, and MAPK kinase inhibitor, PD098059. " 03/11/2004 - "genistein, tyrphostin AG213, piceatannol, tyrphostin AG490, WHI-P97, WHI-P131, Syk antisense) in animal models of allergic asthma have been reported. "
2.	Squamous Cell Carcinoma (Epidermoid Carcinoma) 08/01/1994 - "We have utilized a tyrphostintype inhibitor of the EGF receptor tyrosine kinase domain (RG50864) to study EGF-dependent proliferation and phosphorylation in two human squamous cell carcinoma cell lines. "
3.	Wounds and Injuries (Trauma) 03/01/1994 - "The time to wound closure in HUVEC monolayers was doubled by tyrphostin AG 213 treatment. "
4.	Neoplasms (Cancer) 11/01/1995 - "The programmed cell death inducing effect of the EGF receptor tyrosine kinase inhibitor alpha-cyano-3,4-dihydroxycinnamthioamide (AG213) was investigated in vitro on HT-29 human colon tumor. "
5.	Hyperplasia 11/01/1995 - "When two tyrosine kinase inhibitors (tyrphostins RG50864 and RG13022) were incorporated into the treatment regimens, the TPA-induced epidermal hyperplasia and cell proliferation were effectively blocked, and the TPA-stimulated EGFr tyrosine phosphorylation was significantly reduced. "

Related Drugs and Biologics

1.	Genistein
2.	Protein-Tyrosine Kinases (Tyrosine Kinase)
3.	ErbB Receptors (EGF Receptor)
4.	Epidermal Growth Factor (EGF)
5.	Mitogen-Activated Protein Kinase Kinases (MEKs)
6.	2- (2- amino- 3- methoxyphenyl)- 4H- 1- benzopyran- 4- one
7.	Tyrphostins
8.	Tyrosine Kinase Inhibitors
9.	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)
10.	Shiga Toxin (Shigella Toxin)

Related Therapies and Procedures

1.	Estrogen Replacement Therapy