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factor IX San Dimas

substitution of Glu for Arg at position 4 in the propeptide leads to incomplete gamma-carboxylation & altered phospholipid binding properties

Also Known As:

San Dimas factor IX

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1
- Enzyme Precursors: 724
  - Factor IX: 1840
    - factor IX San Dimas: 1
Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Blood Proteins: 12459
    - Blood Coagulation Factors: 5376
      - Factor IX: 1840
        factor IX San Dimas: 1
  - Protein Precursors: 37
    - Enzyme Precursors: 724
      - Factor IX: 1840
        factor IX San Dimas: 1
Biological Factors: 2472
- Blood Coagulation Factors: 5376
  - Factor IX: 1840
    - factor IX San Dimas: 1

Related Diseases

1.

Hemophilia B (Haemophilia B)

07/05/1989 - "DNA sequence analysis of the Factor IX gene from a hemophilia B patient (98% Factor IX antigen; less than 0.01 unit/ml clotting activity) has identified a point mutation in exon II. A guanine to adenine transition causes the substitution of a glutamine codon for an arginine codon at -4 in the propeptide of Factor IX. This variant, termed Factor IX San Dimas, circulates in the plasma as proFactor IX with a mutant 18-amino acid propeptide still attached. "

Related Drugs and Biologics

1.	Guanine
2.	Glutamine (L-Glutamine)
3.	Factor IX (Coagulation Factor IX)
4.	Codon (Codons)
5.	Arginine (L-Arginine)
6.	Antigens
7.	Adenine
8.	Acids