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2,2-bis(bromomethyl)-1,3-propanediol

structure given in first source

Also Known As:

2,2-BBMPD

Networked: 3 relevant articles (0 outcomes, 3 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Alcohols: 595
  - Glycols: 38
    - Propylene Glycols: 2
      - 2,2-bis(bromomethyl)-1,3-propanediol: 3

Experts

1.	Matsumoto, Kyomu: 1 article (07/2014)
2.	Takahashi, Naofumi: 1 article (07/2014)
3.	Wada, Kunio: 1 article (07/2014)
4.	Yoshida, Toshinori: 1 article (07/2014)
5.	National Toxicology Program: 1 article (10/2005)

Related Diseases

1.	Carcinogenesis 05/01/1996 - "NTP Toxicology and Carcinogenesis Studies of 2,2-Bis(Bromomethyl)-1,3-Propanediol (FR-1138(R)) (CAS No. 3296-90-0) in F344 Rats and B6C3F1 Mice (Feed Studies)." 10/01/2005 - "NTP carcinogenesis studies of 2,2-bis(bromomethyl)-1,3-propanediol, nitromethane, and 1,2,3-trichloropropane (cas nos. 3296-90-0, 75-52-5, and 96-18-4) in guppies (Poecilia reticulata) and medaka (Oryzias latipes) (Waterborne Studies)." 07/15/2014 - "In this study, we examined whether the in vivo comet assay can distinguish between genotoxic and non-genotoxic DNA damage in urinary bladder cells, by using the following seven chemicals related to urinary bladder carcinogenesis in rodents: N-butyl-N-(4-hydroxybutyl)nitrosamine (BBN), glycidol, 2,2-bis(bromomethyl)-1,3-propanediol (BMP), 2-nitroanisole (2-NA), benzyl isothiocyanate (BITC), uracil, and melamine. "
2.	Neoplasms (Cancer) 05/01/1996 - "There was clear evidence of carcinogenic activity of 2,2-bis(bromomethyl)-1,3-propanediol in female B6C3F1 mice based on increased incidences of neoplasms of the harderian gland, lung, and subcutaneous tissue. " 05/01/1996 - "There was clear evidence of carcinogenic activity of 2,2-bis(bromomethyl)-1,3-propanediol in male B6C3F1 mice based on increased incidences of neoplasms of the harderian gland, lung, and kidney. " 05/01/1996 - "There was clear evidence of carcinogenic activity of 2,2-bis(bromomethyl)-1,3-propanediol in female F344/N rats based on increased incidences of neoplasms of the oral cavity, esophagus, mammary gland, and thyroid gland. " 05/01/1996 - "Exposure of female mice to 2,2-bis(bromomethyl)-1,3-propanediol was associated with increased incidences of neoplasms of the harderian gland, lung, and skin. "
3.	Hyperplasia 05/01/1996 - "Exposure of mice to 2,2-bis(bromomethyl)-1,3-propanediol was associated with hyperplasia of the alveolar epithelium in females. " 05/01/1996 - "Exposure of male and female rats to 2,2-bis(bromomethyl)-1,3-propanediol was associated with alveolar/bronchiolar hyperplasia in the lung (males only); focal atrophy, papillary degeneration, transitional epithelial hyperplasia (pelvis), and papillary epithelial hyperplasia in the kidney; follicular cell hyperplasia in the thyroid gland (males only); hyperplasia in the seminal vesicle and pancreas (males only); mucosal hyperplasia in the forestomach (males only); and urinary bladder hyperplasia (males only). "
4.	Chromosome Aberrations (Chromosome Abnormalities) 05/01/1996 - "In cultured Chinese hamster ovary cells, 2,2-bis(bromomethyl)-1,3-propanediol induced chromosomal aberrations only in the presence of S9; no induction of sister chromatid exchanges was observed in cultured Chinese hamster ovary cells after treatment with 2,2-bis(bromomethyl)-1,3-propanediol, with or without S9. "
5.	Body Weight (Weight, Body) 05/01/1996 - "Average daily doses of 2,2-bis(bromomethyl)-1,3-propanediol were 100, 200, or 430 mg/kg body weight for males and 115, 230, or 460 mg/kg for females. "

Related Drugs and Biologics

1.	Uracil
2.	Butylhydroxybutylnitrosamine
3.	benzyl isothiocyanate
4.	melamine
5.	1,2,3-trichloropropane
6.	nitromethane
7.	2-nitroanisole
8.	glycidol

Related Therapies and Procedures

1.	Aftercare (After-Treatment)