4- (3- (biotinylaminohexamethylenaminocarbonyl)propanoylaminomethyl)- 2- methyl- 1,3- dithiolane- 2- yl- (Ala(7))phalloidin

structure given in first source

Also Known As:

BHPP

Networked: 4 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Imidazoles: 150
      - Biotin: 4061
        4-(3-(biotinylaminohexamethylenaminocarbonyl)propanoylaminomethyl)-2-methyl-1,3-dithiolane-2-yl-(Ala(7))phalloidin: 4
Enzymes and Coenzymes: 1
- Coenzymes: 558
  - Biotin: 4061
    - 4-(3-(biotinylaminohexamethylenaminocarbonyl)propanoylaminomethyl)-2-methyl-1,3-dithiolane-2-yl-(Ala(7))phalloidin: 4
Polycyclic Compounds: 6
- Macrocyclic Compounds: 15
  - Cyclic Peptides: 530
    - Phalloidine: 250
      - 4-(3-(biotinylaminohexamethylenaminocarbonyl)propanoylaminomethyl)-2-methyl-1,3-dithiolane-2-yl-(Ala(7))phalloidin: 4
Amino Acids, Peptides, and Proteins: 1
- Peptides: 82426
  - Cyclic Peptides: 530
    - Phalloidine: 250
      - 4-(3-(biotinylaminohexamethylenaminocarbonyl)propanoylaminomethyl)-2-methyl-1,3-dithiolane-2-yl-(Ala(7))phalloidin: 4
  - Oligopeptides: 519
    - Phalloidine: 250
      - 4-(3-(biotinylaminohexamethylenaminocarbonyl)propanoylaminomethyl)-2-methyl-1,3-dithiolane-2-yl-(Ala(7))phalloidin: 4
Biological Factors: 2472
- Biological Toxins: 20
  - Mycotoxins: 1745
    - Phalloidine: 250
      - 4-(3-(biotinylaminohexamethylenaminocarbonyl)propanoylaminomethyl)-2-methyl-1,3-dithiolane-2-yl-(Ala(7))phalloidin: 4

Experts

1.	Adler, Sharon G: 1 article (01/2005)
2.	Becerra, Diana: 1 article (01/2005)
3.	Clemmons, Breyon: 1 article (01/2005)
4.	Kim, Nancy: 1 article (01/2005)
5.	LaPage, Janine: 1 article (01/2005)
6.	Lanting, Linda: 1 article (01/2005)
7.	Ma, Jun: 1 article (01/2005)
8.	Mandal, Mihirbaran: 1 article (01/2005)
9.	Nast, Cynthia C: 1 article (01/2005)
10.	Natarajan, Rama: 1 article (01/2005)

Related Diseases

1.	Diabetic Nephropathies (Diabetic Nephropathy) 01/01/2005 - "We showed that a 12-LO inhibitor, cinnamyl-3,4-dihydroxy-alpha-cyanocinnamate (CDC) inhibited 12/15-LO activity in vivo and assessed the efficacy of another 12/15-LO inhibitor, N-benzyl-N-hydroxy-5-phenylpentamidine (BHPP), to diminish urinary 12-HETE and ameliorate diabetic nephropathy (DN) over 4 months. "
2.	Neoplasms (Cancer) 01/01/1994 - "Tumor cells, upon adhesion to endothelium, initiated 12(S)-HETE biosynthesis, which was inhibited by pretreating tumor cells with BHPP but not with ASA. " 08/01/1997 - "NDGA, a general LOX inhibitor and BHPP, a 12-LOX-selective inhibitor, induced rapid and dose-dependent apoptosis of serum-cultured W256 cells as well as several other tumor (in particular leukemia) cell lines, thus suggesting a potential role for LOX in mediating serum-supported tumor cell survival. " 01/01/1994 - "Platelet-enhanced, tumor cell-induced endothelial cell retraction was inhibited by treating either tumor cells or platelets with the lipoxygenase inhibitors nordihydroguaiaretic acid or N-benzyl-N-hydroxy-5-phenylpentanamide (BHPP) as well as by PGI2 or its analogs iloprost and ZK96.480 (cicaprost), but not by the cyclooxygenase inhibitor aspirin (ASA). "
3.	Prostatic Neoplasms (Prostate Cancer) 05/01/2002 - "The effect of two 12-LOX inhibitors, Baicalein and N-benzyl-N-hydroxy-5-phenylpentamide (BHPP), on the mechanisms controlling cell cycle progression and apoptosis were examined in two prostate cancer cell lines, PC3 and DU-145. "
4.	Leukemia 08/01/1997 - "NDGA, a general LOX inhibitor and BHPP, a 12-LOX-selective inhibitor, induced rapid and dose-dependent apoptosis of serum-cultured W256 cells as well as several other tumor (in particular leukemia) cell lines, thus suggesting a potential role for LOX in mediating serum-supported tumor cell survival. "

Related Drugs and Biologics

1.	12-Hydroxy-5,8,10,14-eicosatetraenoic Acid
2.	Cyclooxygenase Inhibitors
3.	Lipoxygenase Inhibitors
4.	Iloprost (Ventavis)
5.	Masoprocol (Actinex)
6.	Aspirin (Acetylsalicylic Acid)
7.	N-benzyl-N-hydroxy-5-phenylpentanamide
8.	N-benzyl-N-hydroxy-5-phenylpentamide
9.	cicaprost
10.	baicalein