S-nitrosocaptopril

manifests nitrovasodilatory activity, inhibits angiotensin converting enzyme activity & inhibits platelet aggregation

Also Known As:

L-Proline, 1-(2-methyl-3-(nitrosothio)-1-oxopropyl)-, (S)-

Networked: 8 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Amino Acids: 30675
  - Cyclic Amino Acids: 3
    - Imino Acids: 11
      - Proline: 3391
        Captopril: 5230
        S-nitrosocaptopril: 8

Experts

1.	Jia, Lee: 4 articles (01/2019 - 12/2003)
2.	Cheng, Yunlong: 2 articles (01/2019 - 11/2016)
3.	Lian, Shu: 2 articles (01/2019 - 11/2016)
4.	Lu, Yusheng: 2 articles (01/2019 - 11/2016)
5.	Xie, Xiaodong: 2 articles (01/2019 - 11/2016)
6.	Ye, Yuying: 2 articles (01/2019 - 11/2016)
7.	Yu, Ting: 2 articles (01/2019 - 11/2016)
8.	Gao, Yu: 1 article (01/2019)
9.	Liang, Haiyan: 1 article (01/2019)
10.	Xie, Jingjing: 1 article (01/2019)

Related Diseases

1.	Neoplasms (Cancer) 07/28/2010 - "We monitored the effect of S-nitrosocaptopril in TLT tumors using non rinvasive magnetic resonance techniques. " 11/15/2016 - "S-nitrosocaptopril interrupts adhesion of cancer cells to vascular endothelium by suppressing cell adhesion molecules via inhibition of the NF-кB and JAK/STAT signal pathways in endothelial cells." 01/01/2019 - "S-Nitrosocaptopril prevents cancer metastasis in vivo by creating the hostile bloodstream microenvironment against circulating tumor cells." 07/28/2010 - "In an effort to improve the issue of radiotherapy treatments, we tested whether S-nitrosocaptopril, a molecule combining a NO donor and an angiotensin converting enzyme inhibitor (ACE inhibitor), could temporarily improve the hemodynamic status of experimental tumors. "
2.	Hypertension (High Blood Pressure) 07/31/1998 - "In rats with acute hypertension induced by NG-monomethyl-L-arginine (L-NMMA, 30 mg/kg, i.v.), S-nitrosocaptopril (0.125 mg/kg, i.v.) significantly abolished the hypertensive effects. " 06/01/1989 - "S-nitrosocaptopril is a novel hybrid molecule that has potential use in the treatment of hypertension regardless of renin status, angina pectoris and congestive heart failure."
3.	Neuroblastoma 12/01/2003 - "Prostate carcinoma cells (PC-3, LNCaP) and neuroblastoma cells (SKNDZ, CHP212) were used to investigate both transmembrane permeability and cytotoxicity of Taxol in the presence and absence of S-nitrosocaptopril (CapNO), a nitric oxide donating compound. "
4.	Neoplasm Metastasis (Metastasis) 01/01/2019 - "To prevent the cascade from sparking, we show that, the multifunctional S-nitrosocaptopril (CapNO) acts on both CTCs and platelets to interrupt platelet/CTCs interplay and adhesion to endothelium, thus inhibiting CTC-based pulmonary metastasis in vivo. " 01/01/2019 - "S-Nitrosocaptopril prevents cancer metastasis in vivo by creating the hostile bloodstream microenvironment against circulating tumor cells."
5.	Circulating Neoplastic Cells 01/01/2019 - "S-Nitrosocaptopril prevents cancer metastasis in vivo by creating the hostile bloodstream microenvironment against circulating tumor cells."

Related Drugs and Biologics

1.	omega-N-Methylarginine (NG Monomethyl L Arginine)
2.	Paclitaxel (Taxol)
3.	Cell Adhesion Molecules
4.	Renin
5.	Oxygen (Dioxygen)
6.	Nitric Oxide (Nitrogen Monoxide)
7.	Angiotensin-Converting Enzyme Inhibitors (ACE Inhibitors)

Related Therapies and Procedures

1.	Radiotherapy