melanin-concentrating hormone precursors

contains 132-amino acid residues; two forms are known, both share 107 amino acid residues; amino acid sequence in first source; RN refers to pre-pro-MCH-2 isomer; GenBank AF064698 (human)

Also Known As:

pre-pro-MCH; pre-pro-MCH-1; pro-MCH; pro-melanin-concentrating hormone; promelanin-concentrating hormone

Networked: 4 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Alachkar, Amal: 1 article (10/2020)
2.	Alhassen, Lamees: 1 article (10/2020)
3.	Alhassen, Wedad: 1 article (10/2020)
4.	Civelli, Olivier: 1 article (10/2020)
5.	Dai, Qi: 1 article (10/2020)
6.	Hamzeh, Abdul Rezzak: 1 article (10/2020)
7.	Pauluk, Lucas: 1 article (10/2020)
8.	Sakr, Jasmine: 1 article (10/2020)
9.	Sanathara, Nayna: 1 article (10/2020)
10.	Schulmann, Anton: 1 article (10/2020)

Related Diseases

1.	Schizophrenia (Dementia Praecox) 10/01/2020 - "MCHR1 expression is decreased in the prefrontal cortex of schizophrenia samples (false discovery rate (FDR) P < .05, CommonMind and PsychEncode combined datasets, n = 901) while pro-melanin concentrating hormone is below the detection threshold. " 10/01/2020 - "We analyzed MCHR1 and pro-melanin concentrating hormone RNA-Seq expression in the prefrontal cortex in schizophrenia patients and healthy controls. "
2.	Obesity 12/05/2007 - "Following our report of a linkage at 12q24 with a phenotype of obesity under antipsychotics, we tested the pro-melanin-concentrating hormone (PMCH) candidate gene for a possible association in humans with the body mass index (BMI; kg/m2) in unrelated schizophrenic patients (SZ) receiving antipsychotics (N = 300) and in controls (CTL; N = 150). "
3.	Urinary Bladder Neoplasms (Bladder Cancer) 04/01/2009 - "In hypothalamus, DHEA and DHT significantly up-regulated the gene expression of hypocretin (Hcrt; also called orexin), pro-melanin-concentrating hormone (Pmch), and protein kinase C delta (Prkcd), and down-regulated the expression of deleted in bladder cancer chromosome region candidate 1 (Dbccr1) and chitinase 3-like 3 (Chi3l3). "
4.	Major Affective Disorder 2 01/01/1994 - "At least one possible candidate gene for manic depressive illness, pro-melanin-concentrating hormone, is located on chromosome 12q23-q24. "

Related Drugs and Biologics

1.	Protein Kinase C-delta
2.	Antipsychotic Agents (Antipsychotics)
3.	RNA (Ribonucleic Acid)
4.	Dehydroepiandrosterone (DHEA)
5.	Chitinases
6.	Orexins